Carboxymethylated Sulfated Heteroexopolysaccharide from a Haloarchaeal Strain as Potential Biomolecule for Harmless Adjuvant Therapy in Cancer Treatment
Joint Authors
Cherif, Ameur
Najjari, Afef
Ouzari, Hadda
Cherif, Hanene
Chouchane, Habib
Sghaier, Haïtham
Neifar, Mohamed
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This study explored the possible use of a microbial carboxymethylated sulfated heteroexopolysaccharide (CS-hEPS) as a potential anticancer agent.
The investigation was carried out through antioxidant, antifatigue, and antiproliferative activities.
Antioxidant potential including scavenging DPPH and hydroxyl radical activities and reducing power was evaluated.
Antifatigue activity was determined by assessing the endurance of mice using the forced swimming test.
Following 30 days of CS-hEPS oral treatment at different doses, biochemical parameters related to fatigue such as lactic dehydrogenase (LDH), serum urea nitrogen (SUN), and hepatic glycogen (HG) contents were measured.
Antitumor activities were investigated against human cancer liver and myelogenous leukemia cells.
Results showed that CS-hEPS possesses notable antioxidant, antifatigue, and antitumor effects.
CS-hEPS significantly inhibited the proliferation of leukemia (86.6 ± 0.32%) and cancer liver (58.6 ± 0.43%) cells.
CS-hEPS are promising natural antioxidant, antifatigue, and antitumor harmless adjuvant materials that could be applied in human cancer therapy.
American Psychological Association (APA)
Chouchane, Habib& Najjari, Afef& Cherif, Hanene& Neifar, Mohamed& Sghaier, Haïtham& Ouzari, Hadda…[et al.]. 2020. Carboxymethylated Sulfated Heteroexopolysaccharide from a Haloarchaeal Strain as Potential Biomolecule for Harmless Adjuvant Therapy in Cancer Treatment. Journal of Chemistry،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1182472
Modern Language Association (MLA)
Chouchane, Habib…[et al.]. Carboxymethylated Sulfated Heteroexopolysaccharide from a Haloarchaeal Strain as Potential Biomolecule for Harmless Adjuvant Therapy in Cancer Treatment. Journal of Chemistry No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1182472
American Medical Association (AMA)
Chouchane, Habib& Najjari, Afef& Cherif, Hanene& Neifar, Mohamed& Sghaier, Haïtham& Ouzari, Hadda…[et al.]. Carboxymethylated Sulfated Heteroexopolysaccharide from a Haloarchaeal Strain as Potential Biomolecule for Harmless Adjuvant Therapy in Cancer Treatment. Journal of Chemistry. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1182472
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182472