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Telomeric G-Quadruplexes: From Human to Tetrahymena Repeats
Joint Authors
Viglasky, Viktor
Krafčíková, Petra
Demkovičová, Erika
Halaganová, Andrea
Tlučková, Katarína
Tóthova, Petra
Valušová, Eva
Bauer, Lubos
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-28
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The human telomeric and protozoal telomeric sequences differ only in one purine base in their repeats; TTAGGG in telomeric sequences; and TTGGGG in protozoal sequences.
In this study, the relationship between G-quadruplexes formed from these repeats and their derivatives is analyzed and compared.
The human telomeric DNA sequence G3(T2AG3)3 and related sequences in which each adenine base has been systematically replaced by a guanine were investigated; the result is Tetrahymena repeats.
The substitution does not affect the formation of G-quadruplexes but may cause differences in topology.
The results also show that the stability of the substituted derivatives increased in sequences with greater number of substitutions.
In addition, most of the sequences containing imperfections in repeats which were analyzed in this study also occur in human and Tetrahymena genomes.
Generally, the presence of G-quadruplex structures in any organism is a source of limitations during the life cycle.
Therefore, a fuller understanding of the influence of base substitution on the structural variability of G-quadruplexes would be of considerable scientific value.
American Psychological Association (APA)
Demkovičová, Erika& Bauer, Lubos& Krafčíková, Petra& Tlučková, Katarína& Tóthova, Petra& Halaganová, Andrea…[et al.]. 2017. Telomeric G-Quadruplexes: From Human to Tetrahymena Repeats. Journal of Nucleic Acids،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1182483
Modern Language Association (MLA)
Demkovičová, Erika…[et al.]. Telomeric G-Quadruplexes: From Human to Tetrahymena Repeats. Journal of Nucleic Acids No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1182483
American Medical Association (AMA)
Demkovičová, Erika& Bauer, Lubos& Krafčíková, Petra& Tlučková, Katarína& Tóthova, Petra& Halaganová, Andrea…[et al.]. Telomeric G-Quadruplexes: From Human to Tetrahymena Repeats. Journal of Nucleic Acids. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1182483
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182483