Coumarins and Polar Constituents from Eupatorium triplinerve and Evaluation of Their α-Glucosidase Inhibitory Activity
Joint Authors
Viet Huong, Do Thi
Giang, Phan Minh
Trang, Vu Minh
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In our study of antidiabetic compounds from the leaves of Eupatorium triplinerve Vahl.
(Asteraceae), ten compounds were isolated from the methanol leaf extract.
They were determined to be β-sitosterol (1), stigmasterol (2), β-sitosterol 3-O-β-D-glucopyranoside (3), ayapanin (4), ayapin (5), thymoquinol 5-O-β-D-glucopyranoside (6), thyrsifloside (8), (E)-4-methoxymelilotoside (9), and kaempferol 3,7-di-O-β-D-glucopyranoside (10) by using ESI-MS, 1D (1H-, 13C-, DEPT) and 2D NMR (HSQC, HMBC, and NOESY) techniques.
This is the first report of water-soluble compounds from E.
triplinerve and compounds 6–10 were isolated for the first time from E.
triplinerve.
NMR profiling and HPLC analysis are fast and reliable methods to screen phytochemicals in plant samples.
Due to their high concentrations in the leaf extracts of E.
triplinerve, coumarins 4 and 5 could be fast screened by NMR profiling and RP-HPLC-PDA analysis.
In the in vitro test for α-glucosidase inhibition of compounds 4–9, compounds 4, 5, and 7 showed the enzymatic inhibition of 40%, 46%, and 81%, respectively, at 256 μg/mL.
An IC50 value of 58.65 ± 1.20 μg/mL (302 μM) was calculated for compound 7 which is lower than that of the positive control acarbose (IC50 197.33 ± 2.51 μg/mL; 306 μM).
American Psychological Association (APA)
Viet Huong, Do Thi& Giang, Phan Minh& Trang, Vu Minh. 2020. Coumarins and Polar Constituents from Eupatorium triplinerve and Evaluation of Their α-Glucosidase Inhibitory Activity. Journal of Chemistry،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1182486
Modern Language Association (MLA)
Viet Huong, Do Thi…[et al.]. Coumarins and Polar Constituents from Eupatorium triplinerve and Evaluation of Their α-Glucosidase Inhibitory Activity. Journal of Chemistry No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1182486
American Medical Association (AMA)
Viet Huong, Do Thi& Giang, Phan Minh& Trang, Vu Minh. Coumarins and Polar Constituents from Eupatorium triplinerve and Evaluation of Their α-Glucosidase Inhibitory Activity. Journal of Chemistry. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1182486
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182486