Protective Effect of Sika Deer (Cervus nippon) Velvet Antler Extract against Cisplatin-Induced Kidney and Liver Injury in a Prostate Cancer PC-3 Cell Xenograft Model
Joint Authors
Kim, Eun-Kyung
Tang, Yujiao
Wang, Yanmei
Fan, Meiqi
Choi, Young-Jin
Choi, Eun-Ju
Debnath, Trishna
Lee, Il Nam
Moon, Sang-Ho
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-11
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
We previously discovered the antioxidant and antiprostate cancer effects of antler extract (AE), but whether it inhibits cisplatin- (Cis-) induced toxicity has not been investigated.
In this study, the effect of AE on Cis-induced side effects in the kidney and liver using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide-based cytotoxicity and cell cycle assays in prostate cancer PC-3 cells in vitro is investigated.
Furthermore, we used a xenograft mouse model of the same cells to examine the in vivo effects and mechanisms of action.
Cis and Cis + AE treatment attenuated prostate cancer cell growth by inducing apoptosis in vitro.
Cis + AE stimulated cleaved caspases 3, 7, and 9 and polyadenosine diphosphate ribose polymerase expression.
Cis + AE treatment for 1 week significantly increased the superoxide dismutase and catalase antioxidant activity while thiobarbituric acid reactive substances decreased.
The histopathological damage and tumor necrosis factor-α, interleukin- (IL-) 1β and IL-6, cyclooxygenase-2, and inducible nitric oxide synthase expression in the kidney and liver tissue decreased.
Therefore, AE likely possesses antiprostate cancer activity and inhibits Cis toxicity.
American Psychological Association (APA)
Tang, Yujiao& Fan, Meiqi& Choi, Young-Jin& Choi, Eun-Ju& Moon, Sang-Ho& Debnath, Trishna…[et al.]. 2018. Protective Effect of Sika Deer (Cervus nippon) Velvet Antler Extract against Cisplatin-Induced Kidney and Liver Injury in a Prostate Cancer PC-3 Cell Xenograft Model. Journal of Chemistry،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1182518
Modern Language Association (MLA)
Tang, Yujiao…[et al.]. Protective Effect of Sika Deer (Cervus nippon) Velvet Antler Extract against Cisplatin-Induced Kidney and Liver Injury in a Prostate Cancer PC-3 Cell Xenograft Model. Journal of Chemistry No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1182518
American Medical Association (AMA)
Tang, Yujiao& Fan, Meiqi& Choi, Young-Jin& Choi, Eun-Ju& Moon, Sang-Ho& Debnath, Trishna…[et al.]. Protective Effect of Sika Deer (Cervus nippon) Velvet Antler Extract against Cisplatin-Induced Kidney and Liver Injury in a Prostate Cancer PC-3 Cell Xenograft Model. Journal of Chemistry. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1182518
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182518