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Modification of Mesoporous Silica Surface by Immobilization of Functional Groups for Controlled Drug Release
Author
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This paper introduces the synthesis of mesoporous silica nanoparticles (MSNs) with three different groups such as amine, thiol, and sulfonic acid, along the internal surface.
Trimethyl[3-(trimethoxysilyl)propyl]ammonium chloride was used to modify the external surface of the nanomaterials.
Such materials allow control of the drug release from MSN pores.
Multifunctional MSNs were loaded with doxycycline (Doxy) to study their capacities and uploading time.
The loading profile indicates that sulfonic groups in the internal surface were the most efficient surfaces with a loading capacity of ca.
35% in 90 min in acidic media.
American Psychological Association (APA)
Alswieleh, Abdullah M.. 2020. Modification of Mesoporous Silica Surface by Immobilization of Functional Groups for Controlled Drug Release. Journal of Chemistry،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1182523
Modern Language Association (MLA)
Alswieleh, Abdullah M.. Modification of Mesoporous Silica Surface by Immobilization of Functional Groups for Controlled Drug Release. Journal of Chemistry No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1182523
American Medical Association (AMA)
Alswieleh, Abdullah M.. Modification of Mesoporous Silica Surface by Immobilization of Functional Groups for Controlled Drug Release. Journal of Chemistry. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1182523
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182523