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Drug Effect of Thulium(III)-Arsenazo III Complex on Herring Sperm DNA
Joint Authors
Li, Hongbo
Lei, Shutao
Tang, Yongqiong
Zou, Liyuan
Hu, Hongqin
Wang, Suqin
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
To assess the potential cytostatic properties of the thulium(III)-arsenazo III complex as a probe of rare earth complex antitumor drugs, the interaction information of the thulium(III)-arsenazo III complex with DNA was obtained by using spectroscopy, viscosity measurements, and voltammetric methods.
The thermodynamic functions demonstrated that the binding constants of the thulium(III)-arsenazo III complex with DNA were Kθ298.15K = 4.84 × 106 L·mol−1 and Kθ308.15K = 4.48 × 106 L·mol−1, and the binding process was enthalpy driven.
The increase in relative viscosity of DNA with the addition of the thulium(III)-arsenazo III complex and the results from Scatchard and voltammetric methods showed that the interaction mode between the thulium(III)-arsenazo III complex and DNA was groove binding along with weak intercalative binding.
American Psychological Association (APA)
Li, Hongbo& Lei, Shutao& Tang, Yongqiong& Zou, Liyuan& Hu, Hongqin& Wang, Suqin. 2018. Drug Effect of Thulium(III)-Arsenazo III Complex on Herring Sperm DNA. Journal of Chemistry،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1182560
Modern Language Association (MLA)
Li, Hongbo…[et al.]. Drug Effect of Thulium(III)-Arsenazo III Complex on Herring Sperm DNA. Journal of Chemistry No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1182560
American Medical Association (AMA)
Li, Hongbo& Lei, Shutao& Tang, Yongqiong& Zou, Liyuan& Hu, Hongqin& Wang, Suqin. Drug Effect of Thulium(III)-Arsenazo III Complex on Herring Sperm DNA. Journal of Chemistry. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1182560
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182560