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Facile Synthesis of Propranolol and Novel Derivatives
Joint Authors
Bach, Long Giang
Le, Van Thuan
Nguyen, Tan Tai
Nguyen, Thuong Thi
Nguyen, T.-Anh-Nga
Tran, Vy Anh
Tran, Nguyen Hai Tai
Nguyen, Trinh Duy
Vo, The Ky
Vo, Thu-Thao Thi
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Propranolol is one of the first medications of the beta-blocker used for antihypertensive drugs.
This study reports the facile route for the synthesis of propranolol and its novel derivatives.
Herein, propranolol synthesis proceeded from 1-naphthol and isopropylamine under mild and less toxic conditions.
Novel propranolol derivatives were designed by reactions of propranolol with benzoyl chloride, pyridinium chlorochromate, and n-butyl bromide through esterification, oxidation reduction, and alkylation, respectively.
The isolation and purity of compounds were conducted using column chromatography and thin-layer chromatography.
Mass spectrometry and 1H-NMR spectroscopy were applied to identify new compounds structure.
Propranolol derivatives from 2-chlorobenzoyl chloride (compound 3), 2-fluorobenzoyl chloride (compound 5), and especially acetic anhydride (compound 6) manifested high yields and significantly increased water solubility.
Six semisynthetic propranolol derivatives promise to improve antioxidative and biological activities.
American Psychological Association (APA)
Tran, Vy Anh& Tran, Nguyen Hai Tai& Bach, Long Giang& Nguyen, Trinh Duy& Nguyen, Thuong Thi& Nguyen, Tan Tai…[et al.]. 2020. Facile Synthesis of Propranolol and Novel Derivatives. Journal of Chemistry،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1182564
Modern Language Association (MLA)
Tran, Vy Anh…[et al.]. Facile Synthesis of Propranolol and Novel Derivatives. Journal of Chemistry No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1182564
American Medical Association (AMA)
Tran, Vy Anh& Tran, Nguyen Hai Tai& Bach, Long Giang& Nguyen, Trinh Duy& Nguyen, Thuong Thi& Nguyen, Tan Tai…[et al.]. Facile Synthesis of Propranolol and Novel Derivatives. Journal of Chemistry. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1182564
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182564