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Investigation into Polyurethane at Varying Dose Rates of Ionizing Radiation for Clinical Application
Joint Authors
Cooke, Shelley L.
Whittington, Abby R.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Polyurethanes (PUs) are commonly used materials for medical devices.
These devices are exposed repeatedly to radiation when patients undergo radiotherapy treatments.
It has been found that peripherally inserted central catheters (PICCs) and central venous catheters (CVCs) fail at an increased rate (14.7% and 8.8%, respectively) when radiated.
Currently, little research is available on increased failure seen in conjunction with radiation, but complex in vivo environments within a human patient make it difficult to isolate effects of individual variables.
This research investigated effects of radiation in an aqueous environment to determine whether radiation combined with a mimicked in vivo environment is sufficient to change PU devices.
The following dose rates were used in this study: 3.2 Gy·min−1, 4.5 Gy·min−1, 44 Gy·min−1, and 833 Gy·min−1.
Samples were characterized in four main ways: cellular response, physical changes, chemical changes, and mechanical changes.
Results reveal normal cellular response at all dose rates, indicating dose rate does not alter cellular adhesion or proliferation, and biocompatibility of the material is not being altered.
Results from physical, chemical, and mechanical effects confirm that varying dose rates alone do not initiate material changes, which negates the hypothesis that varying dose rates of radiation contribute to the complications in PICC and CVCs.
American Psychological Association (APA)
Cooke, Shelley L.& Whittington, Abby R.. 2018. Investigation into Polyurethane at Varying Dose Rates of Ionizing Radiation for Clinical Application. Journal of Chemistry،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1182565
Modern Language Association (MLA)
Cooke, Shelley L.& Whittington, Abby R.. Investigation into Polyurethane at Varying Dose Rates of Ionizing Radiation for Clinical Application. Journal of Chemistry No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1182565
American Medical Association (AMA)
Cooke, Shelley L.& Whittington, Abby R.. Investigation into Polyurethane at Varying Dose Rates of Ionizing Radiation for Clinical Application. Journal of Chemistry. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1182565
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182565