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Microfluidic Preparation of Liposomes Using Ethyl Acetaten-Hexane Solvents as an Alternative to Chloroform
Joint Authors
Chang, Pahn-Shick
Park, Kyung-Min
Yu, Hyunjong
Park, Jun-Young
Yang, Eunhye
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Although liposomes have been used as a nutrient delivery carrier in the pharmaceutical, cosmetic, and food industries, they still suffer from the critical issue caused by the use of halogenated solvents (e.g., chloroform), which may be harmful to humans.
Nonhalogenated solvents have been screened as candidate substitutes for chloroform based on their physicochemical properties.
However, none of the candidates examined to date could form stable inverted micelles when used alone.
Here, to obtain physicochemical properties similar to chloroform, combined mixtures were prepared using various ratios of each candidate.
Based on the results of random combination trials with numerous candidates, ethyl acetate: n-hexane = 4 : 1(v/v) was selected as the optimum ratio because it could form stable inverted micelles and a transparent liposome solution without phase separation.
The ethyl acetate and n-hexane mixture are a potential substitute for chloroform, which may resolve concerns regarding the toxicity of residual halogenated solvents in lipid nanovesicles.
American Psychological Association (APA)
Yang, Eunhye& Yu, Hyunjong& Park, Jun-Young& Park, Kyung-Min& Chang, Pahn-Shick. 2018. Microfluidic Preparation of Liposomes Using Ethyl Acetaten-Hexane Solvents as an Alternative to Chloroform. Journal of Chemistry،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1182586
Modern Language Association (MLA)
Yang, Eunhye…[et al.]. Microfluidic Preparation of Liposomes Using Ethyl Acetaten-Hexane Solvents as an Alternative to Chloroform. Journal of Chemistry No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1182586
American Medical Association (AMA)
Yang, Eunhye& Yu, Hyunjong& Park, Jun-Young& Park, Kyung-Min& Chang, Pahn-Shick. Microfluidic Preparation of Liposomes Using Ethyl Acetaten-Hexane Solvents as an Alternative to Chloroform. Journal of Chemistry. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1182586
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182586