Physalin B Suppresses Inflammatory Response to Lipopolysaccharide in RAW264.7 Cells by Inhibiting NF-κB Signaling

Abstract EN

Physalin B from Physalis angulata L.

(Solanaceae) is a naturally occurring secosteroid with multiple biological activities.

But its anti-inflammatory activity and mechanism remain unclear.

Physalin B effects on RAW264.7 macrophages stimulated by lipopolysaccharide (LPS) were observed in this study.

The expression and secretion of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) induced by LPS were significantly inhibited by physalin B.

Meanwhile, the NF-κB nuclear translocation induced by LPS was inhibited by physalin B.

The anti-inflammatory effects of physalin B could not be inhibited by mifepristone (RU486), the blocker of glucocorticoid receptor.

In conclusion, physalin B can suppress inflammatory response to LPS in macrophages by inhibiting the production of inflammatory cytokines via NF-κB signaling.