Synthesis, Characterization, and Antimicrobial Studies of Novel Series of 2,4-Bis(hydrazino)-6-substituted-1,3,5-triazine and Their Schiff Base Derivatives
Joint Authors
Solkamy, Essam N.
Al-Rasheed, Hessa H.
Al Alshaikh, Monirah
Al-Obaidi, Ahmed S.
El-Faham, Ayman
Siddiqui, M. Rafiq H.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The present work represents the synthesis, characterization, and antimicrobial studies of novel series of 2,4-bis(hydrazino)-6-substituted-1,3,5-triazine and their Schiff base derivatives.
IR, NMR (H1 and C13), elemental analysis, and LC-MS characterized the prepared compounds.
The biological activity of the target products was evaluated as well.
Twenty-two of the prepared compounds were selected according to their solubility in aqueous DMSO.
Only eight compounds showed good activity against the selected pathogenic bacteria and did not show antagonistic effect against fungus Candida albicans.
Two compounds 4k and 5g have wide-range effect presently in Gram-positive and Gram-negative bacteria while other compounds (4f, 4i, 4m, 5d, 6i, and 6h) showed specific effect against the Gram-negative or Gram-positive bacteria.
The minimum inhibitory concentration (MIC, μg/mL) of 4f, 4i, 4k, and 6h compounds against Streptococcus mutans was 62.5 μg/mL, 100 μg/mL, 31.25 μg/mL, and 31.25 μg/mL, respectively.
The MIC of 4m, 4k, 5d, 5g, and 6h compounds against Staphylococcus aureus was 62.5 μg/mL, 31.25 μg/mL, 31.25 μg/mL, 100 μg/mL, and 62.5 μg/mL, respectively.
The MIC of 4k, 5g, and 6i compounds against Salmonella typhimurium was 31.25 μg/mL, 100 μg/mL, and 62.5 μg/mL, respectively.
The MIC of 6i compound against Escherichia coli was 62.5 μg/mL.
American Psychological Association (APA)
Al-Rasheed, Hessa H.& Solkamy, Essam N.& Al Alshaikh, Monirah& Siddiqui, M. Rafiq H.& Al-Obaidi, Ahmed S.& El-Faham, Ayman. 2018. Synthesis, Characterization, and Antimicrobial Studies of Novel Series of 2,4-Bis(hydrazino)-6-substituted-1,3,5-triazine and Their Schiff Base Derivatives. Journal of Chemistry،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1182644
Modern Language Association (MLA)
Al-Rasheed, Hessa H.…[et al.]. Synthesis, Characterization, and Antimicrobial Studies of Novel Series of 2,4-Bis(hydrazino)-6-substituted-1,3,5-triazine and Their Schiff Base Derivatives. Journal of Chemistry No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1182644
American Medical Association (AMA)
Al-Rasheed, Hessa H.& Solkamy, Essam N.& Al Alshaikh, Monirah& Siddiqui, M. Rafiq H.& Al-Obaidi, Ahmed S.& El-Faham, Ayman. Synthesis, Characterization, and Antimicrobial Studies of Novel Series of 2,4-Bis(hydrazino)-6-substituted-1,3,5-triazine and Their Schiff Base Derivatives. Journal of Chemistry. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1182644
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182644