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Synthesis, Characterization, X-Ray Crystallography, and Antileishmanial Activities of N-Linked and O-Linked Glycopyranosides
Joint Authors
Yousuf, Sammer
ur Rashid, Haroon
Rehman, Noor
Khan, Sher Wali
Khan, Momin
Tariq, Muhammad
Nadhman, Akhtar
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Novel N-linked 5a–e and O-linked glycopyranosides 7a–e were synthesized in high yield from commercially available L-tartaric acid containing two asymmetric centers and C2 axis of symmetry.
The compound L-tartaric acid was completely protected and then partially hydrolyzed to get the monoester, which upon treatment with different amino and hydroxyl derivatives of glycopyranoses gave the desired amides and esters.
The synthesized derivatives were purified by chromatography and characterized by spectroanalytical techniques.
The structure of compound 7c in the series was supported by X-ray analysis.
Leishmanicidal activities of compounds 5a–e and 7a–e were investigated which showed moderate to good activities.
American Psychological Association (APA)
ur Rashid, Haroon& Khan, Sher Wali& Khan, Momin& Nadhman, Akhtar& Rehman, Noor& Tariq, Muhammad…[et al.]. 2018. Synthesis, Characterization, X-Ray Crystallography, and Antileishmanial Activities of N-Linked and O-Linked Glycopyranosides. Journal of Chemistry،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1182759
Modern Language Association (MLA)
ur Rashid, Haroon…[et al.]. Synthesis, Characterization, X-Ray Crystallography, and Antileishmanial Activities of N-Linked and O-Linked Glycopyranosides. Journal of Chemistry No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1182759
American Medical Association (AMA)
ur Rashid, Haroon& Khan, Sher Wali& Khan, Momin& Nadhman, Akhtar& Rehman, Noor& Tariq, Muhammad…[et al.]. Synthesis, Characterization, X-Ray Crystallography, and Antileishmanial Activities of N-Linked and O-Linked Glycopyranosides. Journal of Chemistry. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1182759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182759