pH-Responsive TiO2 Nanotube Drug Delivery System Based on Iron Coordination
Joint Authors
Liu, Yan
Xie, Chunling
Zhang, Fengfen
Xiao, Xiufeng
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Nanostructured materials play a fundamental role in orthopedic research owing to their outstanding properties and excellent biocompatibility.
Titania nanotube (TNT) arrays engineered by electrochemical anodization process have been extensively explored and used as effective carriers for controlled drug delivery.
In this study, we proposed a drug delivery system based on coordination bond.
Iron (III), Fe3+, on the nanotube surface can effectively bind to alendronate sodium (NaAL), a drug for the treatment of osteoporosis, through coordination bonds, which can be formed or broken through the change of pH, and thus can be controlled by pH.
The pH-responsive system was prepared by three-step procedure: (i) fabrication of TNTs by electrochemical anodization, (ii) modification of amino groups on the surface of nanotubes by hydrothermal method, and (iii) amino-functionalized nanotubes by Fe3+ solution soak.
The Fe-modified TNTs not only allowed alendronate-loading content of up to 50.2% by weight, which is significantly higher than most drug delivery systems previously reported, but also delayed and prolonged drug release.
Moreover, in vitro drug release experiments demonstrated that coordination bond-based TNT system may have great potential applications in clinical use.
American Psychological Association (APA)
Liu, Yan& Xie, Chunling& Zhang, Fengfen& Xiao, Xiufeng. 2019. pH-Responsive TiO2 Nanotube Drug Delivery System Based on Iron Coordination. Journal of Nanomaterials،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1182761
Modern Language Association (MLA)
Liu, Yan…[et al.]. pH-Responsive TiO2 Nanotube Drug Delivery System Based on Iron Coordination. Journal of Nanomaterials No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1182761
American Medical Association (AMA)
Liu, Yan& Xie, Chunling& Zhang, Fengfen& Xiao, Xiufeng. pH-Responsive TiO2 Nanotube Drug Delivery System Based on Iron Coordination. Journal of Nanomaterials. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1182761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182761