Preparation and Characterisation of Nobiletin-Loaded Nanostructured Lipid Carriers

Joint Authors

Huang, Wei
Dou, Huating
Wu, Houjiu
Sun, Zhigao
Wang, Hua
Huang, Linhua

Source

Journal of Nanomaterials

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-08-17

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Chemistry
Civil Engineering

Abstract EN

The objective of this manuscript was to investigate and optimise the potential of nanostructured lipid carriers (NLCs) as a carrier system for nobiletin (NOB), which was prepared by high-pressure homogenisation method.

Additionally, this study was focused on the application of NOB-loaded NLC (NOB-NLC) in functional food.

Response surface method with a three-level Box–Behnken design was validated through analysis of variance, and the robustness of the design was confirmed through the correspondence between the values measured in the experiments and the predicted ones.

Properties of the prepared NOB-NLC, such as Z-average, polydispersity, entrapment efficiency, zeta potential, morphology, and crystallinity, were investigated.

NOB-NLC exhibited a spherical shape with a diameter of 112.27 ± 5.33 nm, zeta potential of −35.1 ± 2.94 mV, a polydispersity index of 0.251 ± 0.058, and an EE of 81.06% ± 6.02%.

Results from X-ray diffraction and differential scanning calorimetry of NOB-NLC reviewed that the NOB crystal might be converted to an amorphous state.

Fourier transform infrared spectroscopic analysis demonstrated that chemical interaction was absent between the compound and lipid mixture in NOB-NLC.

American Psychological Association (APA)

Huang, Wei& Dou, Huating& Wu, Houjiu& Sun, Zhigao& Wang, Hua& Huang, Linhua. 2017. Preparation and Characterisation of Nobiletin-Loaded Nanostructured Lipid Carriers. Journal of Nanomaterials،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1182845

Modern Language Association (MLA)

Huang, Wei…[et al.]. Preparation and Characterisation of Nobiletin-Loaded Nanostructured Lipid Carriers. Journal of Nanomaterials No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1182845

American Medical Association (AMA)

Huang, Wei& Dou, Huating& Wu, Houjiu& Sun, Zhigao& Wang, Hua& Huang, Linhua. Preparation and Characterisation of Nobiletin-Loaded Nanostructured Lipid Carriers. Journal of Nanomaterials. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1182845

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1182845