TfR mAb-Cross-Linked RituximabMTX-PEG-PLL-PLGA Drug-Loaded Nanoparticles Enhance Anticancer Action in B Lymphocytes
Joint Authors
Chen, Baoan
Liu, Ran
Zhao, Gang
Wang, Shujun
Gu, Yan
Han, Qi
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Nanoparticles could enhance the drug targeted to the cancer cell by the enrichment of the drug levels, which leads to the improvement of the codelivery of both drugs for an antitumor effect.
In the current study, we reported an efficient, local drug-loaded delivery strategy with a nanoparticle-loaded system.
After the synthesis of Rituximab/MTX-PEG-PLL-PLGA, the transferrin receptor monoantibody (TfR mAb) was subsequently cross-linked to the nanoparticles.
Compared to the traditional drug, the nanoparticle-loaded system can precisely and efficiently transport the Rituximab and Methotrexate (MTX) drug into SU-DHL-4 cells, a typical kind of B lymphocytes, which can significantly increase the cell apoptosis in the SU-DHL-4 cells.
Thus, the multifunctional drug-loaded nanoparticles displayed the persistent stability and precise targeting properties, which enhanced the efficiency of anticancer efficiency in B lymphocytes.
American Psychological Association (APA)
Liu, Ran& Zhao, Gang& Wang, Shujun& Gu, Yan& Han, Qi& Chen, Baoan. 2019. TfR mAb-Cross-Linked RituximabMTX-PEG-PLL-PLGA Drug-Loaded Nanoparticles Enhance Anticancer Action in B Lymphocytes. Journal of Nanomaterials،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1182915
Modern Language Association (MLA)
Liu, Ran…[et al.]. TfR mAb-Cross-Linked RituximabMTX-PEG-PLL-PLGA Drug-Loaded Nanoparticles Enhance Anticancer Action in B Lymphocytes. Journal of Nanomaterials No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1182915
American Medical Association (AMA)
Liu, Ran& Zhao, Gang& Wang, Shujun& Gu, Yan& Han, Qi& Chen, Baoan. TfR mAb-Cross-Linked RituximabMTX-PEG-PLL-PLGA Drug-Loaded Nanoparticles Enhance Anticancer Action in B Lymphocytes. Journal of Nanomaterials. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1182915
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182915