Synthesis, Characterization, and In Vitro Drug Delivery of Chitosan-Silica Hybrid Microspheres for Bone Tissue Engineering
Joint Authors
Qian, Haisheng
Niu, Niu
Teng, Shu-Hua
Zhou, Hua-Jian
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Chitosan-silica (CS-SiO2) hybrid microspheres were prepared through the combined process of sol-gel and emulsification-crosslinking.
Their composition, morphology, in vitro bioactivity, and drug release behavior were investigated.
The results showed that, when 20 wt% SiO2 was incorporated, the as-prepared CS-SiO2 hybrid microspheres exhibited a regular spherical shape, a high dispersity, and a uniform microstructure.
Their average particle diameter was determined to be about 24.0 μm.
The in situ deposited inorganic phase of the hybrid microspheres was identified as amorphous SiO2, and its actual content was determined by the TG analysis.
As compared with the pure chitosan microspheres, the CS-SiO2 hybrid microspheres displayed a greatly improved in vitro bioactivity.
Vancomycin hydrochloride (VH) was selected as a model drug.
It was demonstrated that the CS-SiO2 hybrid microspheres presented a good capacity for both loading and sustained release of VH.
Moreover, the increase of the SiO2 content efficiently slowed down the drug release rate of the CS-SiO2 hybrid microspheres.
American Psychological Association (APA)
Niu, Niu& Teng, Shu-Hua& Zhou, Hua-Jian& Qian, Haisheng. 2019. Synthesis, Characterization, and In Vitro Drug Delivery of Chitosan-Silica Hybrid Microspheres for Bone Tissue Engineering. Journal of Nanomaterials،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1182952
Modern Language Association (MLA)
Niu, Niu…[et al.]. Synthesis, Characterization, and In Vitro Drug Delivery of Chitosan-Silica Hybrid Microspheres for Bone Tissue Engineering. Journal of Nanomaterials No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1182952
American Medical Association (AMA)
Niu, Niu& Teng, Shu-Hua& Zhou, Hua-Jian& Qian, Haisheng. Synthesis, Characterization, and In Vitro Drug Delivery of Chitosan-Silica Hybrid Microspheres for Bone Tissue Engineering. Journal of Nanomaterials. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1182952
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182952