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Reduction in Serum High-Sensitivity C-Reactive Protein Favors Kidney Outcomes in Patients with Impaired Fasting Glucose or Diabetes
Joint Authors
Zhao, Ming-hui
Wu, Shouling
Liu, Lili
Gao, Bixia
Wang, Jinwei
Yang, Chao
Wu, Yuntao
Chen, Shuohua
Li, Qiuyun
Zhang, Huifen
Wang, Guodong
Chen, Min
Zhang, Luxia
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
We aimed to evaluate whether the reduction in serum high-sensitivity C-reactive protein (hs-CRP) favors kidney outcomes.
Methods.
This study was a subanalysis including patients with impaired fasting glucose or diabetes of the Kailuan cohort study.
The predictor was based on two consecutive visits of hs-CRP levels in 2006 and 2008.
A total of 3924 patients with hs-CRP≥3 mg/L in 2006 were divided into two groups according to whether the levels of hs-CRP were reduced in 2008: Group 1: no reduction: hs-CRP≥3 mg/L in 2008; Group 2: reduction: hs-CRP<3 mg/L in 2008.
Kidney outcomes include kidney function decline and development and progression of proteinuria and were followed up until the end of 2015.
Results.
There were 3905, 2049, and 493 patients included into our analysis for the outcomes of kidney function decline and the development and progression of proteinuria, respectively.
A total of 398, 297, and 47 events occurred after 5 years of follow-up, respectively.
Cox regression revealed that patients with reduction in hs-CRP have lower risk of kidney function decline (HR 0.71, 95% CI 0.57-0.89, and P=0.002) and development of proteinuria (0.77, 0.61-0.99, and P=0.038) after controlling for potential confounders as compared to those with no reduction in hs-CRP levels.
Conclusions.
Reduction in serum hs-CRP levels favors kidney outcomes in patients with impaired fasting glucose or diabetes.
American Psychological Association (APA)
Liu, Lili& Gao, Bixia& Wang, Jinwei& Yang, Chao& Wu, Shouling& Wu, Yuntao…[et al.]. 2020. Reduction in Serum High-Sensitivity C-Reactive Protein Favors Kidney Outcomes in Patients with Impaired Fasting Glucose or Diabetes. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1182977
Modern Language Association (MLA)
Liu, Lili…[et al.]. Reduction in Serum High-Sensitivity C-Reactive Protein Favors Kidney Outcomes in Patients with Impaired Fasting Glucose or Diabetes. Journal of Diabetes Research No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1182977
American Medical Association (AMA)
Liu, Lili& Gao, Bixia& Wang, Jinwei& Yang, Chao& Wu, Shouling& Wu, Yuntao…[et al.]. Reduction in Serum High-Sensitivity C-Reactive Protein Favors Kidney Outcomes in Patients with Impaired Fasting Glucose or Diabetes. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1182977
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182977