Pyruvate-Enriched Oral Rehydration Solution Improves Glucometabolic Disorders in the Kidneys of Diabetic dbdb Mice
Joint Authors
Deng, Hao
Zhang, Xiao Meng
Tong, Jin Dong
Wang, Yi Zhen
Ning, Xu Chao
Yang, Xiu Hong
Zhou, Fang Qiang
Jin, Hui Min
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-25
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Diabetes is prevalent worldwide, but ideally intensive therapeutic strategy in clinical diabetes and diabetic nephropathy (DN) is still lack.
Pyruvate is protective from glucometabolic disturbances and kidney dysfunction in various pathogenic insults.
Present studies focused on oral pyruvate effects on diabetes status and DN with 0.35% pyruvate in pyruvate-enriched oral rehydration solution (Pyr-ORS) and 1% pyruvate as drinking water for 8 weeks, using the model of diabetic db/db mice.
Both Pyr-ORS and 1% pyruvate showed comparable therapeutic effectiveness with controls of body weight and blood sugar, increases of blood insulin levels, and improvement of renal function and pathological changes.
Aberrant key enzyme activities in glucometabolic pathways, AR, PK, and PDK/PDH, were also restored; indexes of oxidative stress and inflammation, NAD+/NADH ratio, and AGEs in the kidneys were mostly significantly preserved after pyruvate treatments.
We concluded that oral pyruvate delayed DN progression in db/db mice and the modified Pyr-ORS formula might be an ideal novel therapeutic drink in clinical prevention and treatment of type 2 diabetes and DN.
American Psychological Association (APA)
Zhang, Xiao Meng& Deng, Hao& Tong, Jin Dong& Wang, Yi Zhen& Ning, Xu Chao& Yang, Xiu Hong…[et al.]. 2020. Pyruvate-Enriched Oral Rehydration Solution Improves Glucometabolic Disorders in the Kidneys of Diabetic dbdb Mice. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1182985
Modern Language Association (MLA)
Zhang, Xiao Meng…[et al.]. Pyruvate-Enriched Oral Rehydration Solution Improves Glucometabolic Disorders in the Kidneys of Diabetic dbdb Mice. Journal of Diabetes Research No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1182985
American Medical Association (AMA)
Zhang, Xiao Meng& Deng, Hao& Tong, Jin Dong& Wang, Yi Zhen& Ning, Xu Chao& Yang, Xiu Hong…[et al.]. Pyruvate-Enriched Oral Rehydration Solution Improves Glucometabolic Disorders in the Kidneys of Diabetic dbdb Mice. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1182985
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182985