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A Comparison of the Association of Fasting Plasma Glucose and HbA1c Levels with Diabetic Retinopathy in Japanese Men
Joint Authors
Nakamura, Yosuke
Noda, Mitsuhiko
Matsushita, Yumi
Takeda, Norio
Yamamoto, Shuichiro
Yokoyama, Tetsuji
Mizoue, Tetsuya
Nakagawa, Toru
Yoshida-Hata, Natsuyo
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
The relationship between HbA1c and diabetic retinopathy is expected to differ between different races.
This study was designed to verify whether HbA1c or fasting plasma glucose (FPG) is more effective in detecting diabetic retinopathy in a Japanese population.
Materials and Methods.
The study subjects underwent health examinations between 2008 and 2009 with fasting.
Of these participants, we analyzed the data for 2,921 Japanese men who had undergone an ophthalmologic examination.
Retinopathy was classified into 7 categories according to a simplified diabetic retinopathy scale.
The odds ratios of retinopathy according to the eight groups of FPG and HbA1c were estimated using multiple logistic regression analysis adjusted for age.
Receiver operator characteristic analysis was used to evaluate each value associated with the presence or absence of retinopathy.
Results and Discussion.
The odds ratios (95% CI) of retinopathy for HbA1c level categories, in ascending order, were 1.0 (ref.), 0.88 (0.28-2.75), 1.27 (0.44-3.69), 1.52 (0.48-4.79), 1.89 (0.52-6.85), 2.70 (0.66-11.10), 4.10 (0.80-21.00), and 6.34 (2.37-16.97) where the odds ratios significantly increased with HbA1c≥6.8%.
The area under the curve (SE) for FPG and HbA1c was almost the same, at 0.668 (0.043) and 0.680 (0.043), respectively.
Conclusions.
It was clarified that the higher the level of HbA1c, the higher the prevalence of retinopathy, and there was no clear threshold.
The detection ability of retinopathy was almost the same, suggesting that it is possible to detect the risk of retinopathy by HbA1c only.
American Psychological Association (APA)
Matsushita, Yumi& Takeda, Norio& Nakamura, Yosuke& Yoshida-Hata, Natsuyo& Yamamoto, Shuichiro& Noda, Mitsuhiko…[et al.]. 2020. A Comparison of the Association of Fasting Plasma Glucose and HbA1c Levels with Diabetic Retinopathy in Japanese Men. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1183021
Modern Language Association (MLA)
Matsushita, Yumi…[et al.]. A Comparison of the Association of Fasting Plasma Glucose and HbA1c Levels with Diabetic Retinopathy in Japanese Men. Journal of Diabetes Research No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1183021
American Medical Association (AMA)
Matsushita, Yumi& Takeda, Norio& Nakamura, Yosuke& Yoshida-Hata, Natsuyo& Yamamoto, Shuichiro& Noda, Mitsuhiko…[et al.]. A Comparison of the Association of Fasting Plasma Glucose and HbA1c Levels with Diabetic Retinopathy in Japanese Men. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1183021
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183021