Characterization and Evaluation of a Folic Acid Receptor-Targeted NorcantharidinTetrandrine Dual-Drug Loaded Delivery System
Joint Authors
Xiong, Youxiang
Tang, Hongxia
Liu, Wenhong
Zhang, Tingting
Ma, Rui
Mu, Chaofeng
Zhu, Zhihong
Li, Fanzhu
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-27
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The objective of this study was to construct norcantharidin (NCTD)/tetrandrine (Tet) dual-drug loaded lipid nanoparticles (FA-LP@Tet/(MSNs@NCTD)) based on mesoporous silica nanoparticles (MSNs) for controlling drug release and lowering their systemic toxicity.
In this study, MSNs were prepared and used for encapsulating anticancer drug NCTD; then MSNs@NCTD and Tet were loaded into liposomes to construct dual-drug loaded lipid nanoparticles with folic acid (FA) as the targeting moiety.
The prepared dual-drug loaded lipid nanoparticles with a uniform particle size distribution of 153.17±4.17 nm (PDI 0.191±0.017, zeta potential -20.93±1.75 mV), had a visible core-shell structure under transmission electron microscopy; the encapsulation efficiency of NCTD and Tet was 86.62% and 79.19%, respectively, with obvious in vitro sustained release characteristics.
The cellular uptake results suggested that FA modification could enhance intracellular distribution of FA-LP@Tet/(MSNs@NCTD).
Furthermore, cell apoptosis assays showed FA-LP@Tet/(MSNs@NCTD) had better antitumor ability via reversing multidrug resistance.
Therefore, FA-LP@Tet/(MSNs@NCTD) was a promising drug delivery system for combination cancer therapy.
American Psychological Association (APA)
Xiong, Youxiang& Tang, Hongxia& Liu, Wenhong& Zhang, Tingting& Ma, Rui& Mu, Chaofeng…[et al.]. 2019. Characterization and Evaluation of a Folic Acid Receptor-Targeted NorcantharidinTetrandrine Dual-Drug Loaded Delivery System. Journal of Nanomaterials،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1183046
Modern Language Association (MLA)
Xiong, Youxiang…[et al.]. Characterization and Evaluation of a Folic Acid Receptor-Targeted NorcantharidinTetrandrine Dual-Drug Loaded Delivery System. Journal of Nanomaterials No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1183046
American Medical Association (AMA)
Xiong, Youxiang& Tang, Hongxia& Liu, Wenhong& Zhang, Tingting& Ma, Rui& Mu, Chaofeng…[et al.]. Characterization and Evaluation of a Folic Acid Receptor-Targeted NorcantharidinTetrandrine Dual-Drug Loaded Delivery System. Journal of Nanomaterials. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1183046
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183046