Tinidazole Delivery Improved by Nanosized Minicells Originated from Leuconostoc mesenteroides
Joint Authors
Vu Kinh, Luan
Nguyen Anh, Dung
Romero Jovel, Santa
Nguyen Hoang Khue, Tu
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A nanoparticle originating from natural products used as a drug delivery is considered as one of the indispensable issues in the pharmaceutical field.
Increasing the bioavailability of a drug and prolonging the effect of the drug are important.
Tinidazole is an antifungal agent that has absorption interfered by food.
This study reported the ability of Leuconostoc mesenteroides VTCC B-871 in producing nanosized minicells used as drug delivery for tinidazole to improve the passage to the eaten mouse intestinal membrane.
By using a scanning electron microscope and a transmission electron microscope, the morphology of the minicell loading drug was observed.
The spherical shape and size (400 nm) of minicells did not change over time when kept in buffered saline gelatin and packaged with tinidazole.
Based on Box-Behnken design, the optimal conditions were selected for actual encapsulation.
Minicells could encapsulate tinidazole approximately to 90% which was determined by high-performance liquid chromatography analysis.
The maximal concentration of tinidazole released from minicells was 70% at pH 3.4 and 55% at pH 7.2, respectively.
The absorption ability of tinidazole packaging minicells was quantified in mice.
Tinidazole loading minicells could be absorbed faster than tinidazole alone in fed mice via oral administration.
The study assessed that the absorption of water-insoluble tinidazole could be improved by Leuconostoc minicells without inhibition by food effects.
American Psychological Association (APA)
Vu Kinh, Luan& Nguyen Anh, Dung& Romero Jovel, Santa& Nguyen Hoang Khue, Tu. 2019. Tinidazole Delivery Improved by Nanosized Minicells Originated from Leuconostoc mesenteroides. Journal of Nanomaterials،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1183053
Modern Language Association (MLA)
Vu Kinh, Luan…[et al.]. Tinidazole Delivery Improved by Nanosized Minicells Originated from Leuconostoc mesenteroides. Journal of Nanomaterials No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1183053
American Medical Association (AMA)
Vu Kinh, Luan& Nguyen Anh, Dung& Romero Jovel, Santa& Nguyen Hoang Khue, Tu. Tinidazole Delivery Improved by Nanosized Minicells Originated from Leuconostoc mesenteroides. Journal of Nanomaterials. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1183053
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183053