Elevated Midtrimester Triglycerides as a Biomarker for Postpartum Hyperglycemia in Gestational Diabetes
Joint Authors
Ma, Yuhang
Wang, Yufan
Xu, Xianming
Lai, Mengyu
Fang, Fang
Yang, Jiaying
Huang, Jingjing
Li, Na
Kang, Mei
Zhang, Jiarong
Peng, Yongde
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Whether elevated triglyceride (TG) levels during pregnancy were a biomarker for postpartum abnormal glucose metabolism (AGM) in women with previous gestational diabetes mellitus (GDM) remained unknown.
The aim of this study was to investigate the association between TG levels during the second trimester and postpartum AGM in GDM women.
Methods.
This was a retrospective cohort study including 513 GDM women.
A 75 g oral glucose tolerance test (OGTT) was performed, and lipid levels were determined during pregnancy and the postpartum period.
GDM patients were categorized into tertiles according to their TG levels at 24–28 weeks of gestation (TG<2.14 mmol/L, TG: 2.14–2.89 mmol/L, and TG>2.89 mmol/L).
A logistic regression model was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs).
Results.
During pregnancy, women in the high TG tertile showed higher HbA1c levels (5.47±0.58% versus 5.28±0.49%, p=0.006), higher total cholesterol (TC) levels (5.85±1.23 mmol/L versus 5.15±0.97 mmol/L, p=0.026), and higher HOMA-IR (2.36 (1.62-3.45) versus 1.49 (0.97-2.33), p<0.001) than the participants in the low TG tertile.
After delivery, the prevalence rates of AGM based on above tertiles of TG levels during pregnancy were 26.90%, 33.33%, and 43.27%, respectively (p=0.006).
High TG tertile during the second trimester was associated with the presence of postpartum AGM (adjusted OR: 2.001, 95% CI: 1.054-3.800, p=0.034).
Conclusions.
The elevated midtrimester TG levels were not only accompanied by higher glucose and lipid levels and more severe insulin resistance at the time of the measurement but were a biomarker for postpartum AGM as well.
American Psychological Association (APA)
Lai, Mengyu& Fang, Fang& Ma, Yuhang& Yang, Jiaying& Huang, Jingjing& Li, Na…[et al.]. 2020. Elevated Midtrimester Triglycerides as a Biomarker for Postpartum Hyperglycemia in Gestational Diabetes. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1183085
Modern Language Association (MLA)
Lai, Mengyu…[et al.]. Elevated Midtrimester Triglycerides as a Biomarker for Postpartum Hyperglycemia in Gestational Diabetes. Journal of Diabetes Research No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1183085
American Medical Association (AMA)
Lai, Mengyu& Fang, Fang& Ma, Yuhang& Yang, Jiaying& Huang, Jingjing& Li, Na…[et al.]. Elevated Midtrimester Triglycerides as a Biomarker for Postpartum Hyperglycemia in Gestational Diabetes. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1183085
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183085