Dual-Drug-Loaded Silk FibroinPLGA Scaffolds for Potential Bone Regeneration Applications
Joint Authors
Zhang, Mei
Sun, Dahui
Yao, Jihang
Wang, Yilong
Ma, Wendi
Dong, Wenying
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-16
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Developing scaffold materials with excellent biocompatibility, mechanical properties, and controlled drug release properties is vital to tissue engineering.
In this study, we fabricated silk fibroin (SF)/poly(lactide-co-glycolide) (PLGA) nanofiber scaffolds containing recombinant human bone morphogenetic protein 2 (rhBMP2) and dexamethasone (DXM) via coaxial electrospinning, which were used in in vitro bone formation with rat bone marrow mesenchymal stem cells (rBMSCs).
An in vitro drug release study was adopted to evaluate the sustained release potential of the core-shell structured nanofibers.
Furthermore, we detected the potential of the SF/PLGA nanofiber membrane in vitro.
In vitro studies showed that rhBMP2 still remained active on the nanofiber membrane.
In addition, the dual-drug-loaded nanofiber membrane showed an early burst release of DXM and late sustained release of rhBMP2.
rhBMP2 and DXM exhibited strong osteogenic differentiation potential when they acted on rBMSCs.
Therefore, the SF/PLGA nanofiber membrane loaded with rhBMP2 and DXM has great potential for the enhancement of bone regeneration.
American Psychological Association (APA)
Yao, Jihang& Wang, Yilong& Ma, Wendi& Dong, Wenying& Zhang, Mei& Sun, Dahui. 2019. Dual-Drug-Loaded Silk FibroinPLGA Scaffolds for Potential Bone Regeneration Applications. Journal of Nanomaterials،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1183099
Modern Language Association (MLA)
Yao, Jihang…[et al.]. Dual-Drug-Loaded Silk FibroinPLGA Scaffolds for Potential Bone Regeneration Applications. Journal of Nanomaterials No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1183099
American Medical Association (AMA)
Yao, Jihang& Wang, Yilong& Ma, Wendi& Dong, Wenying& Zhang, Mei& Sun, Dahui. Dual-Drug-Loaded Silk FibroinPLGA Scaffolds for Potential Bone Regeneration Applications. Journal of Nanomaterials. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1183099
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183099