Association between Serum Ferritin and Blood Lipids: Influence of Diabetes and hs-CRP Levels

Abstract EN

This study is aimed at exploring the relationship between serum ferritin and blood lipids and the influence of diabetes and different hs-CRP levels.

A total of 8163 subjects were analyzed.

Participators were classified according to serum ferritin, diabetes, and two hs-CRP levels.

Blood lipids were determined using standardized methods and conditions.

Except for HDL-C, there was a significant increase in blood lipids in the progressive ferritin group with normal hs-CRP levels (P<0.05).

But HDL-C was just the opposite (P<0.0001).

In nondiabetic patients, TG, TC, and LDL-C were significantly elevated in the progressive ferritin group (P<0.05).

And, HDL-C was just the opposite (P<0.05).

The generalized linear model and the parsimonious model showed that serum TG was positively correlated with ferritin, and LDL-C was negatively correlated with ferritin (P<0.05).

But the correlation between LDL-C and ferritin was broken (P>0.05).

After a sufficient adjustment, there was a positive correlation between serum TG and ferritin and a negative correlation between LDL-C and ferritin.

Nonetheless, a negative correlation between LDL-C and ferritin is influenced by diabetes frailly.

And, there was no change of relationship between lipids and ferritin in different hs-CRP levels.

We found a real relationship between ferritin and lipids after sufficient adjustment for confounders.