Evaluation of the Osteoblast Behavior to PGA Textile Functionalized with RGD as a Scaffold for Bone Regeneration
Joint Authors
Álvarez-Pérez, Marco Antonio
Flores-Reyes, Hector
Escobar-García, Diana María
Magdaleno, Mariné Ortiz
Grandfils, Christian
Pozos-Guillen, Amaury
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The new era of biomaterials for repairing bone tissue injury continues to be a challenge in bone tissue engineering.
The fiber scaffolds allow for cellular interconnection and a microenvironment close to the bone extracellular matrix.
The aim of this study was to evaluate the osteoblast behavior on a 3D textile of PGA (polyglycolic acid) fibers functionalized with the RGD (R: arginine; G: glycine; D: aspartic acid) peptide.
The cell morphology, proliferation, and calcium phosphate deposition ability were evaluated on textiles at different time intervals under a confocal laser scanning microscope.
The osteoblast viability ranged from 92% to 98%, and cell proliferation was higher in PGA-RGD than control PGA (uncoated).
In addition, the osteoblast calcium phosphate deposition was significantly greater on PGA-RGD in osteogenic inductor medium (OIM) in contrast to controls without inducing factors.
The PGA-RGD fibers supported proliferation and viability of osteoblast and stimulated bone osteogenesis and mineralization.
These results support the adoption of this 3D polymeric textile as a scaffold for bone tissue engineering.
American Psychological Association (APA)
Magdaleno, Mariné Ortiz& Escobar-García, Diana María& Álvarez-Pérez, Marco Antonio& Pozos-Guillen, Amaury& Grandfils, Christian& Flores-Reyes, Hector. 2017. Evaluation of the Osteoblast Behavior to PGA Textile Functionalized with RGD as a Scaffold for Bone Regeneration. Journal of Nanomaterials،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1183120
Modern Language Association (MLA)
Magdaleno, Mariné Ortiz…[et al.]. Evaluation of the Osteoblast Behavior to PGA Textile Functionalized with RGD as a Scaffold for Bone Regeneration. Journal of Nanomaterials No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1183120
American Medical Association (AMA)
Magdaleno, Mariné Ortiz& Escobar-García, Diana María& Álvarez-Pérez, Marco Antonio& Pozos-Guillen, Amaury& Grandfils, Christian& Flores-Reyes, Hector. Evaluation of the Osteoblast Behavior to PGA Textile Functionalized with RGD as a Scaffold for Bone Regeneration. Journal of Nanomaterials. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1183120
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183120