Combined Effect of Maternal Vitamin D Deficiency and Gestational Diabetes Mellitus on Trajectories of Ultrasound-Measured Fetal Growth: A Birth Cohort Study in Beijing, China
Joint Authors
Liu, Zheng
Liu, Hui
Xu, Xiangrong
Luo, Shusheng
Liu, Jue
Jin, Chuyao
Han, Na
Wang, Hai-Jun
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
Few studies have examined whether maternal 25(OH)D deficiency and gestational diabetes mellitus (GDM) jointly affect fetal growth.
We aimed to examine the separate and combined effects of maternal 25(OH)D deficiency and GDM on trajectories of fetal growth.
Methods.
We established a birth cohort (2016-2017) with 10,913 singleton pregnancies in Tongzhou Maternal and Child Health Hospital of Beijing, China.
Maternal 25(OH)D deficiency (serum 25OHD concentration<20.0 ng/mL) was detected, and GDM was diagnosed at 24~28 gestational weeks.
Fetal growth was assessed by longitudinal ultrasound measurements of estimated fetal weight (EFW) and abdominal circumference (AC) from 28 gestational weeks to delivery, both of which were standardized as gestational-age-adjusted Z-score.
A k-means algorithm was used to cluster the longitudinal measurements (trajectories) of fetal growth.
Logistic regression models were used for estimating exposure-outcome associations and additive interactions.
Results.
We identified two distinct trajectories of fetal growth, and the faster one resembling the 90th centile curve in the reference population was classified as excessive fetal growth.
Maternal 25(OH)D deficiency and GDM were independently associated with an increased risk of excessive fetal growth.
The combination of maternal 25(OH)D deficiency and GDM was associated with an increased risk of excessive fetal growth assessed by EFW Z-score (odds ratio (OR): 1.36; 95% confidence interval (CI): 1.15~1.62) and AC Z-score (OR (95% CI): 1.32 (1.11~1.56)), but the relative excess risks attributable to interaction were nonsignificant (P>0.05).
Conclusion.
Maternal 25(OH)D deficiency and GDM may jointly increase the risk of excessive fetal growth.
Interventions for pregnancies with GDM may be more beneficial for those with 25(OH)D deficiency than those without regarding risk of excessive fetal growth, if confirmed in a large sample.
American Psychological Association (APA)
Liu, Zheng& Liu, Hui& Xu, Xiangrong& Luo, Shusheng& Liu, Jue& Jin, Chuyao…[et al.]. 2020. Combined Effect of Maternal Vitamin D Deficiency and Gestational Diabetes Mellitus on Trajectories of Ultrasound-Measured Fetal Growth: A Birth Cohort Study in Beijing, China. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1183125
Modern Language Association (MLA)
Liu, Zheng…[et al.]. Combined Effect of Maternal Vitamin D Deficiency and Gestational Diabetes Mellitus on Trajectories of Ultrasound-Measured Fetal Growth: A Birth Cohort Study in Beijing, China. Journal of Diabetes Research No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1183125
American Medical Association (AMA)
Liu, Zheng& Liu, Hui& Xu, Xiangrong& Luo, Shusheng& Liu, Jue& Jin, Chuyao…[et al.]. Combined Effect of Maternal Vitamin D Deficiency and Gestational Diabetes Mellitus on Trajectories of Ultrasound-Measured Fetal Growth: A Birth Cohort Study in Beijing, China. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1183125
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183125