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Comparative Study of Antitumor Activity between Lipophilic Bismuth Nanoparticles (BisBAL NPs) and Chlorhexidine on Human Squamous Cell Carcinoma
Joint Authors
Hernandez-Delgadillo, Rene
Zaragoza-Magaña, Valentin
Chellam, Shankararaman
Cabral-Romero, Claudio
Meester, Irene
Solis-Soto, Juan M.
Martínez-Pérez, Fernando
García-Cuellar, Claudia María
Sánchez-Pérez, Yesennia
Nakagoshi-Cepeda, Sergio Eduardo
Nakagoshi-Cepeda, María Argelia Akemi
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The objective of this study was to compare the antitumor activity of lipophilic bismuth nanoparticles (BisBAL NPs) and chlorhexidine (CHX) on human squamous cell carcinoma.
BisBAL NPs were synthesized by colloidal method and characterized by energy dispersive X-ray spectroscopy in conjunction with scanning electron microscopy (EDS-SEM).
The effect of BisBAL NPs and CHX on oral cancer cell line (CAL-27) and nontumor control cell human gingival fibroblasts (HGFs) was determined by MTT cell viability assay.
The obtained results showed selective inhibition of CAL-27 cell growth by BisBAL nanoclusters.
A 24 h exposition to 25 μM BisBAL NP decreased 91% of CAL-27 cell growth, while nontumor HGFs cells were unaffected by BisBAL NPs showing 90% of cell viability.
In contrast, CHX kills both CAL-27 and HGFs with the same efficacy.
25 μM of CHX decreased 97% and 80% of tumor and nontumoral cell growth.
BisBAL NP and CHX alter cell permeability suggesting that action mechanism may include loss of cell membrane integrity.
Also, CHX and not BisBAL NP presented genotoxicity on genomic DNA of tumor cells.
As conclusion, BisBAL NPs have a selective antitumor activity on human squamous cell carcinoma, unlike CHX which was cytotoxic for both tumoral and nontumoral control cells.
American Psychological Association (APA)
Martínez-Pérez, Fernando& García-Cuellar, Claudia María& Hernandez-Delgadillo, Rene& Zaragoza-Magaña, Valentin& Sánchez-Pérez, Yesennia& Meester, Irene…[et al.]. 2019. Comparative Study of Antitumor Activity between Lipophilic Bismuth Nanoparticles (BisBAL NPs) and Chlorhexidine on Human Squamous Cell Carcinoma. Journal of Nanomaterials،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1183127
Modern Language Association (MLA)
Martínez-Pérez, Fernando…[et al.]. Comparative Study of Antitumor Activity between Lipophilic Bismuth Nanoparticles (BisBAL NPs) and Chlorhexidine on Human Squamous Cell Carcinoma. Journal of Nanomaterials No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1183127
American Medical Association (AMA)
Martínez-Pérez, Fernando& García-Cuellar, Claudia María& Hernandez-Delgadillo, Rene& Zaragoza-Magaña, Valentin& Sánchez-Pérez, Yesennia& Meester, Irene…[et al.]. Comparative Study of Antitumor Activity between Lipophilic Bismuth Nanoparticles (BisBAL NPs) and Chlorhexidine on Human Squamous Cell Carcinoma. Journal of Nanomaterials. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1183127
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183127