Clinical Features of Type B Insulin Resistance in Japanese Patients: Case Report and Survey-Based Case Series Study
Joint Authors
Kadowaki, Takashi
Yamauchi, Toshimasa
Hirota, Yusuke
Suwanai, Hirotsugu
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Type B insulin resistance (TBIR) is an extremely rare disease characterized by marked hyperglycemia and insulin resistance and often coexists with autoimmune diseases.
The characteristics, symptoms, blood glucose patterns, comorbidities, and treatments of TBIR all vary and are not defined.
In this study, we described a case of TBIR that developed 6 months after DPP-4 inhibitor administration and immediately after the patient caught a cold.
Treatment using prednisolone and insulin-like growth factor-1 was effective.
We also conducted an observational survey-based case series study in a Japanese cohort comprising 21 cases.
The average age of onset of TBIR was 62.3±14.8 (17–84) years, and 61.9% of subjects were male.
The majority of patients (90.4%) were 50 years old and over.
During the study period, there was a high percentage (85.7%) of episodes of hypoglycemia, which was the trigger for diagnosis in more than 50% of cases.
Glycemic patterns included 7 cases of hyperglycemia (33.3%), 10 cases of hypoglycemia (47.6%), and 4 cases of both hyperglycemia and hypoglycemia (19.1%).
In the hypoglycemic group, 90.0% of patients were male.
Furthermore, 71.4% of cases were antinuclear antibody positive, and 81.0% of cases were complicated with autoimmune disease.
Systemic lupus erythematosus (38.1%) and Sjögren’s syndrome (23.8%) were relatively common as coexisting autoimmune diseases.
Treatment was based on prednisolone use, which was used in 88.9% of patients.
On the other hand, the effect of IGF-1 was limited.
Overall, the prognosis of TBIR was good.
American Psychological Association (APA)
Hirota, Yusuke& Suwanai, Hirotsugu& Yamauchi, Toshimasa& Kadowaki, Takashi. 2020. Clinical Features of Type B Insulin Resistance in Japanese Patients: Case Report and Survey-Based Case Series Study. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1183135
Modern Language Association (MLA)
Hirota, Yusuke…[et al.]. Clinical Features of Type B Insulin Resistance in Japanese Patients: Case Report and Survey-Based Case Series Study. Journal of Diabetes Research No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1183135
American Medical Association (AMA)
Hirota, Yusuke& Suwanai, Hirotsugu& Yamauchi, Toshimasa& Kadowaki, Takashi. Clinical Features of Type B Insulin Resistance in Japanese Patients: Case Report and Survey-Based Case Series Study. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1183135
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183135