The Mechanism of Metabolic Influences on the Endogenous GLP-1 by Oral Antidiabetic Medications in Type 2 Diabetes Mellitus
Joint Authors
Yuan, Xinlu
Nguyen, Thiquynhnga
Gong, Min
Wen, Song
Jin, Jianlan
Zhou, Ligang
Wang, Chaoxun
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Incretin-based therapy is now a prevalent treatment option for patients with type 2 diabetes mellitus (T2DM).
It has been associated with considerably good results in the management of hyperglycemia with cardiac or nephron-benefits.
For this reason, it is recommended for individuals with cardiovascular diseases in many clinical guidelines.
As an incretin hormone, glucagon-like peptide-1 (GLP-1) possesses multiple metabolic benefits such as optimizing energy usage, maintaining body weight, β cell preservation, and suppressing neurodegeneration.
However, recent studies indicate that oral antidiabetic medications interact with endogenous or exogenous GLP-1.
Since these drugs are transported to distal intestine portions, there are concerns whether these oral drugs directly stimulate intestinal L cells which release GLP-1, or whether they do so via indirect inhibition of the activity of dipeptidyl peptidase-IV (DPP-IV).
In this review, we discuss the metabolic relationships between oral antihyperglycemic drugs from the aspect of gut, microbiota, hormones, β cell function, central nervous system, and other cellular mechanisms.
American Psychological Association (APA)
Nguyen, Thiquynhnga& Gong, Min& Wen, Song& Yuan, Xinlu& Wang, Chaoxun& Jin, Jianlan…[et al.]. 2020. The Mechanism of Metabolic Influences on the Endogenous GLP-1 by Oral Antidiabetic Medications in Type 2 Diabetes Mellitus. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1183144
Modern Language Association (MLA)
Nguyen, Thiquynhnga…[et al.]. The Mechanism of Metabolic Influences on the Endogenous GLP-1 by Oral Antidiabetic Medications in Type 2 Diabetes Mellitus. Journal of Diabetes Research No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1183144
American Medical Association (AMA)
Nguyen, Thiquynhnga& Gong, Min& Wen, Song& Yuan, Xinlu& Wang, Chaoxun& Jin, Jianlan…[et al.]. The Mechanism of Metabolic Influences on the Endogenous GLP-1 by Oral Antidiabetic Medications in Type 2 Diabetes Mellitus. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1183144
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183144