ADIPOQ rs2241766 Gene Polymorphism and Predisposition to Diabetic Kidney Disease
Joint Authors
Geng, Wenjia
Han, Qiuxia
Zhang, Dong
Cai, Guangyan
Zhu, Hanyu
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
This meta-analysis was performed to obtain a more comprehensive estimation of the role of the single nucleotide polymorphism (SNP) rs2241766 in the ADIPOQ gene in the occurrence of diabetic kidney disease (DKD).
Methods.
Relevant studies were identified from digital databases such as Embase, PubMed, Medline, Cochrane Library, Google Scholar, WanFang, and Chinese National Knowledge Infrastructure (CNKI).
Odds ratios (ORs) with their corresponding 95% confidence intervals (95% CIs) were pooled by means of fixed- or random-effects models.
Interstudy heterogeneity was examined using the Q test and I2 statistic, and sensitivity analysis was implemented to test the statistical stability of the overall estimates.
Begg’s funnel plot and Egger’s test were applied to inspect potential publication bias among the included studies.
Results.
The overall ORs reflected a positive correlation between the ADIPOQ rs2241766 polymorphism and susceptibility to DKD in the GG vs.
TT and GG vs.
TT+TG comparisons (OR=1.51, 95%CI=1.16−1.95; OR=1.43, 95%CI=1.11−1.85).
After stratification analyses by ethnicity and disease type, a similar trend was also revealed in the Caucasian and African subgroups as well as in the type 2 diabetes mellitus (T2DM) subgroup.
Conclusion.
The ADIPOQ rs2241766 polymorphism may be associated with an increased risk of DKD, especially in Caucasian and African populations as well as in T2DM patients.
American Psychological Association (APA)
Han, Qiuxia& Geng, Wenjia& Zhang, Dong& Cai, Guangyan& Zhu, Hanyu. 2020. ADIPOQ rs2241766 Gene Polymorphism and Predisposition to Diabetic Kidney Disease. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1183188
Modern Language Association (MLA)
Han, Qiuxia…[et al.]. ADIPOQ rs2241766 Gene Polymorphism and Predisposition to Diabetic Kidney Disease. Journal of Diabetes Research No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1183188
American Medical Association (AMA)
Han, Qiuxia& Geng, Wenjia& Zhang, Dong& Cai, Guangyan& Zhu, Hanyu. ADIPOQ rs2241766 Gene Polymorphism and Predisposition to Diabetic Kidney Disease. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1183188
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183188