Elevated Serum Level of Cytokeratin 18 M65ED Is an Independent Indicator of Cardiometabolic Disorders
Joint Authors
Jia, Weiping
Li, Huating
Zhang, Jing
Fang, Qichen
Qian, Lingling
Zhang, Lei
Wu, Liang
Hou, Xuhong
Gao, Qiongmei
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Recent studies have suggested that cell death might be involved in the pathophysiology of metabolic disorders.
The cytokeratin 18 (CK18) fragment, as a cell death marker, plays an important role in nonalcoholic fatty liver disease (NAFLD).
However, only a limited number of studies have found elevated serum levels of CK18 in patients with type 2 diabetes.
Moreover, no studies have been conducted yet to investigate the role of CK18 in hypertension or dyslipidemia.
In particular, CK18 M65ED is a more sensitive marker of cell death, and its role in cardiometabolic disorders has not been revealed yet.
Methods.
A total of 588 subjects were enrolled from the local communities of Shanghai.
Serum CK18 M65ED were determined using the enzyme-linked immunosorbent assay.
A cardiometabolic disorder was identified by the presence of at least one of the components including overweight or central obesity, diabetes, dyslipidemia, and hypertension.
Results.
Subjects with cardiometabolic disorders exhibited significantly higher serum levels of CK18 M65ED than those without cardiometabolic disorders (197.36 (121.13–354.50) U/L versus 83.85 (52.80–153.75) U/L, respectively, P<0.001).
Increased serum CK18 M65ED quartiles were associated with the increased prevalence of cardiometabolic disorders and its components (P<0.001 for all components).
Multiple stepwise regression analysis also revealed that diastolic blood pressure, glycated hemoglobin A1c, alanine transaminase, and high-density lipoprotein cholesterol were independently correlated with serum CK18 M65ED levels (all P<0.01).
In addition, logistic regression analysis showed that the serum CK18 M65ED levels were positively correlated with cardiometabolic disorders and in an independent manner.
Further, CK18 M65ED was revealed to be an indicator of cardiometabolic disorders in a NAFLD-independent manner.
Conclusions.
Elevated levels of CK18 M65ED, a sensitive cell death marker, were independently and positively correlated with cardiometabolic disorders, even after the adjustment for the presence of NAFLD and other cardiovascular risk factors.
American Psychological Association (APA)
Qian, Lingling& Zhang, Lei& Wu, Liang& Zhang, Jing& Fang, Qichen& Hou, Xuhong…[et al.]. 2020. Elevated Serum Level of Cytokeratin 18 M65ED Is an Independent Indicator of Cardiometabolic Disorders. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1183189
Modern Language Association (MLA)
Qian, Lingling…[et al.]. Elevated Serum Level of Cytokeratin 18 M65ED Is an Independent Indicator of Cardiometabolic Disorders. Journal of Diabetes Research No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1183189
American Medical Association (AMA)
Qian, Lingling& Zhang, Lei& Wu, Liang& Zhang, Jing& Fang, Qichen& Hou, Xuhong…[et al.]. Elevated Serum Level of Cytokeratin 18 M65ED Is an Independent Indicator of Cardiometabolic Disorders. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1183189
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183189