Association between PNPLA2 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in a Chinese Han Population with Type 2 Diabetes
Joint Authors
Zhang, Haojun
Zhao, Tingting
Li, Ping
Yan, Meihua
Ma, Liang
Zhao, Hailing
Wang, Yan
Dong, Xi
Wang, Qian
Li, Jialin
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Diabetic kidney disease (DKD) is one of the most common complications of diabetes and the leading cause of end-stage renal disease.
Here, we investigated the association of PNPLA2 gene variations with DKD susceptibility in a Chinese Han population.
A total of 818 participants with type 2 diabetes were recruited in the case-control study, including 379 patients diagnosed with DKD.
We observed that 2 tagSNPs, PNPLA2 rs28633403 (A>G) and rs1138714 (A>G), were associated with DKD (rs28633403: genotype, P=0.017; allele, P=0.015; rs1138714: genotype, P=0.029; allele, P=0.018).
PNPLA2 rs1138693 (T>C), a missense SNP, showed no association with DKD (genotype, P=0.966; allele, P=0.845).
Genetic model analysis revealed that minor allele G of PNPLA2 rs28633403 was a protective factor of DKD in a dominant model adjusted by confounders (AG+GG vs.
AA: adjusted odds ratio (aOR), 0.619; 95% CI 0.447-0.857; P=0.004) and in an additive model (AG vs.
AA: aOR, 0.633; 95% CI 0.447-0.895; P=0.010; GG vs.
AA: aOR, 0.588; 95% CI 0.385-0.897; P=0.014).
Minor allele G of PNPLA2 rs1138714 was associated with a higher risk of DKD in a dominant model adjusted by confounders (AG+GG vs.
AA: adjusted odds ratio (aOR), 1.531; 95% CI 1.134-2.067; P=0.005) and in an additive model (AG vs.
AA: aOR, 1.529; 95% CI 1.118-2.091; P=0.008).
The combined effect of PNPLA2 rs28633403 AA+rs1138714 AG or GG genotype showed an association with DKD, adjusted by confounders (aOR, 2.194; 95% CI 1.378-3.492; P=0.001), which was considered statistically significant with a markedly increased risk of DKD after a Holm-Bonferroni correction for multiple tests (P<0.00125).
Our results suggest that PNPLA2 rs28633403 and rs1138714 are significantly associated with the risk of DKD in a Chinese Han population with type 2 diabetes.
American Psychological Association (APA)
Zhao, Hailing& Zhang, Haojun& Wang, Yan& Zhao, Tingting& Yan, Meihua& Dong, Xi…[et al.]. 2020. Association between PNPLA2 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in a Chinese Han Population with Type 2 Diabetes. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1183208
Modern Language Association (MLA)
Zhao, Hailing…[et al.]. Association between PNPLA2 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in a Chinese Han Population with Type 2 Diabetes. Journal of Diabetes Research No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1183208
American Medical Association (AMA)
Zhao, Hailing& Zhang, Haojun& Wang, Yan& Zhao, Tingting& Yan, Meihua& Dong, Xi…[et al.]. Association between PNPLA2 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in a Chinese Han Population with Type 2 Diabetes. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1183208
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183208