The Effects of Sleeve Gastrectomy on Glucose Metabolism and Glucagon-Like Peptide 1 in Goto-Kakizaki Rats
Joint Authors
Li, Laiyuan
Wang, Xiaolin
Bai, Liangliang
Yu, Huichuan
Huang, Zenghong
Huang, Anpei
Luo, Yanxin
Wang, Jianping
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Purpose.
To investigate the effects of sleeve gastrectomy (SG) on glucose metabolism and changes in glucagon-like peptide 1 (GLP-1) in Goto-Kakizaki (GK) rats.
Methods.
GK rats were randomly assigned to one of three groups: SG, SG pair-fed plus sham surgery (PF-sham), and ad libitum-fed no surgery (control).
Food intake, body weight, blood glucose, GLP-1 and insulin levels, and GLP-1 expression in the jejunum and ileum were compared.
Results.
The SG rats exhibited lower postoperative food intake, body weight, and fasting glucose than did the control rats (P<0.05).
SG significantly improved glucose and insulin tolerance (P<0.05).
Plasma GLP-1 levels were higher in SG rats than in control or PF-sham rats in the oral glucose tolerance test (OGTT) (P<0.05).
Blood glucose levels expressed as a percentage of baseline were higher in SG rats than in control rats after exendin (9-39) administration (P<0.05).
The levels of GLP-1 expression in the jejunum and ileum were higher in SG rats than in PF-sham and control rats (P<0.05).
Conclusions.
Improvement of glucose metabolism by SG was associated with increased GLP-1 secretion.
SG contributes to an increase in plasma GLP-1 levels via increased GLP-1 expression in the mucosa of the jejunum and/or ileum.
American Psychological Association (APA)
Li, Laiyuan& Wang, Xiaolin& Bai, Liangliang& Yu, Huichuan& Huang, Zenghong& Huang, Anpei…[et al.]. 2018. The Effects of Sleeve Gastrectomy on Glucose Metabolism and Glucagon-Like Peptide 1 in Goto-Kakizaki Rats. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1183235
Modern Language Association (MLA)
Li, Laiyuan…[et al.]. The Effects of Sleeve Gastrectomy on Glucose Metabolism and Glucagon-Like Peptide 1 in Goto-Kakizaki Rats. Journal of Diabetes Research No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1183235
American Medical Association (AMA)
Li, Laiyuan& Wang, Xiaolin& Bai, Liangliang& Yu, Huichuan& Huang, Zenghong& Huang, Anpei…[et al.]. The Effects of Sleeve Gastrectomy on Glucose Metabolism and Glucagon-Like Peptide 1 in Goto-Kakizaki Rats. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1183235
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183235