Glimepiride Administered in Chow Reversibly Impairs Glucose Tolerance in Mice
Joint Authors
Niedowicz, Dana M.
Özcan, Sabire
Nelson, Peter T.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Sulfonylureas are a class of antidiabetes medications prescribed to millions of individuals worldwide.
Rodents have been used extensively to study sulfonylureas in the laboratory.
Here, we report the results of studies treating mice with a sulfonylurea (glimepiride) in order to understand how the drug affects glucose homeostasis and tolerance.
We tested the effect of glimepiride on fasting blood glucose, glucose tolerance, and insulin secretion, using glimepiride sourced from a local pharmacy.
We also examined the effect on glucagon, gluconeogenesis, and insulin sensitivity.
Unexpectedly, glimepiride exposure in mice was associated with fasting hyperglycemia, glucose intolerance, and decreased insulin.
There was no change in circulating glucagon levels or gluconeogenesis.
The effect was dose-dependent, took effect by two weeks, and was reversed within three weeks after removal.
Glimepiride elicited the same effects in all strains evaluated: four wild-type strains, as well as the transgenic Grn−/− and diabetic db/db mice.
Our findings suggest that the use of glimepiride as a hypoglycemic agent in mice should proceed with caution and may have broader implications about mouse models as a proxy to study the human pharmacopeia.
American Psychological Association (APA)
Niedowicz, Dana M.& Özcan, Sabire& Nelson, Peter T.. 2018. Glimepiride Administered in Chow Reversibly Impairs Glucose Tolerance in Mice. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1183248
Modern Language Association (MLA)
Niedowicz, Dana M.…[et al.]. Glimepiride Administered in Chow Reversibly Impairs Glucose Tolerance in Mice. Journal of Diabetes Research No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1183248
American Medical Association (AMA)
Niedowicz, Dana M.& Özcan, Sabire& Nelson, Peter T.. Glimepiride Administered in Chow Reversibly Impairs Glucose Tolerance in Mice. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1183248
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183248