Bile Acids: Key Regulators and Novel Treatment Targets for Type 2 Diabetes
Joint Authors
Wu, Yingjie
Zhou, An
Tang, Li
Lei, Yuanyuan
Tang, Bo
Zhang, Linjing
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Type 2 diabetes mellitus (T2DM), characterized by insulin resistance and unclear pathogenesis, is a serious menace to human health.
Bile acids are the end products of cholesterol catabolism and play an important role in maintaining cholesterol homeostasis.
Furthermore, increasing studies suggest that bile acids may regulate glucose tolerance, insulin sensitivity, and energy metabolism, suggesting that bile acids may represent a potential therapeutic target for T2DM.
This study summarizes the metabolism of bile acids and, more importantly, changes in their concentrations, constitution, and receptors in diabetes.
Furthermore, we provide an overview of the mechanisms underlying the role of bile acids in glucose and lipid metabolism, as well as the occurrence and development of T2DM.
Bile acid-targeted therapy may represent a valid approach for T2DM treatment.
American Psychological Association (APA)
Wu, Yingjie& Zhou, An& Tang, Li& Lei, Yuanyuan& Tang, Bo& Zhang, Linjing. 2020. Bile Acids: Key Regulators and Novel Treatment Targets for Type 2 Diabetes. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1183250
Modern Language Association (MLA)
Wu, Yingjie…[et al.]. Bile Acids: Key Regulators and Novel Treatment Targets for Type 2 Diabetes. Journal of Diabetes Research No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1183250
American Medical Association (AMA)
Wu, Yingjie& Zhou, An& Tang, Li& Lei, Yuanyuan& Tang, Bo& Zhang, Linjing. Bile Acids: Key Regulators and Novel Treatment Targets for Type 2 Diabetes. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1183250
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183250