The Efficacy and Safety of Acellular Matrix Therapy for Diabetic Foot Ulcers: A Meta-Analysis of Randomized Clinical Trials
Joint Authors
Yin, Guo-shu
Xu, Wencan
Wei, Chiju
Huang, Wentao
Chen, Yongsong
Wang, Nasui
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Acellular matrix (AM) therapy has shown promise in the treatment of diabetic foot ulcers (DFUs) in several studies.
The clinical effects of AM therapy were not well established.
Therefore, we conducted a meta-analysis of randomized clinical trials (RCTs) to examine the efficacy and safety of AM therapy for patients with DFUs.
Methods.
A literature search of 5 databases was performed to identify RCTs comparing AM therapy to standard therapy (ST) in patients with DFUs.
The primary outcome was the complete healing rate and the secondary outcomes mainly included time to complete healing and adverse events.
Results.
Nine RCTs involving 897 patients were included.
Compared with ST group, patients allocated to AM group had a higher complete healing rate both at 12 weeks (risk ratio RR=1.73, 95% confidence interval (CI): 1.31 to 2.30) and 16 weeks (RR=1.56, 95% CI: 1.28 to 1.91), a shorter time to complete healing (mean difference MD=−2.41; 95% CI: -3.49 to -1.32), and fewer adverse events (RR=0.64, 95% CI: 0.44 to 0.93).
Conclusion.
The present study suggests that AM therapy as an adjuvant treatment could further promote the healing of full-thickness, noninfected, and nonischemia DFUs.
AM therapy also has a safety profile.
More large well-designed randomized clinical trials with long follow-up duration are needed to further explore the efficacy and safety of AM therapy for DFUs.
American Psychological Association (APA)
Huang, Wentao& Chen, Yongsong& Wang, Nasui& Yin, Guo-shu& Wei, Chiju& Xu, Wencan. 2020. The Efficacy and Safety of Acellular Matrix Therapy for Diabetic Foot Ulcers: A Meta-Analysis of Randomized Clinical Trials. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1183259
Modern Language Association (MLA)
Huang, Wentao…[et al.]. The Efficacy and Safety of Acellular Matrix Therapy for Diabetic Foot Ulcers: A Meta-Analysis of Randomized Clinical Trials. Journal of Diabetes Research No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1183259
American Medical Association (AMA)
Huang, Wentao& Chen, Yongsong& Wang, Nasui& Yin, Guo-shu& Wei, Chiju& Xu, Wencan. The Efficacy and Safety of Acellular Matrix Therapy for Diabetic Foot Ulcers: A Meta-Analysis of Randomized Clinical Trials. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1183259
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183259