Ischemic Postconditioning Mitigates Retinopathy in Tree Shrews with Diabetic Cerebral Ischemia
Joint Authors
Ke, Tingyu
Zhao, Ling
Liao, Qiwei
Zhang, Yueting
Tan, Shufen
Li, Shuqing
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Ischemic postconditioning (PC) is proved to efficiently protect diabetic patients with acute myocardial infarction from ischemia-reperfusion injury.
We aimed to explore the protective roles of ischemic PC on diabetic retinopathy in tree shrews with diabetic cerebral ischemia.
A diabetic tree shrew model was established through high-fat diet feeding combined with streptozotocin (STZ) injection, while cortical thrombotic cerebral ischemia was induced photochemically.
Tree shrews were divided into the normal control group, sham operation group, diabetes mellitus group, diabetes mellitus+cerebral ischemia group, and diabetes mellitus+cerebral ischemia+PC group (in which the tree shrews with diabetic cerebral ischemia were treated with ischemic PC).
H&E staining was used to examine the pathological changes in the retina, and immunohistochemistry was performed to determine the retinal expression of VEGF (vascular endothelial growth factor).
The modeling resulted in 77% tree shrews with diabetes.
Ischemic PC reduced the blood glucose levels in the tree shrews with diabetic cerebral ischemia.
Tree shrews with diabetes had thinned retina with disordered structures, and these pathological changes were aggravated after cerebral ischemia.
The retinopathy was alleviated after ischemic PC.
Retina expression of VEGF was mainly distributed in the ganglion cell layer in tree shrews.
Diabetes and cerebral ischemia increased retinal VEGF expression in a step-wise manner, while additional ischemic PC reduced retinal VEGF expression.
Therefore, ischemic PC effectively alleviates retinopathy in tree shrews with diabetic cerebral ischemia, and this effect is associated with reduced retinal VEGF expression.
American Psychological Association (APA)
Zhao, Ling& Liao, Qiwei& Zhang, Yueting& Tan, Shufen& Li, Shuqing& Ke, Tingyu. 2020. Ischemic Postconditioning Mitigates Retinopathy in Tree Shrews with Diabetic Cerebral Ischemia. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1183261
Modern Language Association (MLA)
Zhao, Ling…[et al.]. Ischemic Postconditioning Mitigates Retinopathy in Tree Shrews with Diabetic Cerebral Ischemia. Journal of Diabetes Research No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1183261
American Medical Association (AMA)
Zhao, Ling& Liao, Qiwei& Zhang, Yueting& Tan, Shufen& Li, Shuqing& Ke, Tingyu. Ischemic Postconditioning Mitigates Retinopathy in Tree Shrews with Diabetic Cerebral Ischemia. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1183261
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183261