Meta-Analysis of 11 Heterogeneous Studies regarding Dipeptidyl Peptidase 4 Inhibitor Add-On Therapy for Type 2 Diabetes Mellitus Patients Treated with Insulin
Joint Authors
Shibuki, Katsuya
Shimada, Shuji
Aoyama, Takao
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Several clinical trials have addressed the therapeutic strategy of adding dipeptidyl peptidase 4 (DPP-4) inhibitors to the treatment of type 2 diabetes mellitus (DM) inadequately controlled by insulin therapy.
However, there is a high degree of heterogeneity in these studies, and the cause of which has not been identified.
Methods.
We conducted a meta-analysis of randomized controlled trials, which compared the efficacy and safety of adding DPP-4 inhibitors or placebo to insulin therapy; the level of hemoglobin A1c (HbA1c) in the patients was >7.0%, and the duration of treatment was ≥8 weeks.
We focused on the mean changes in HbA1c from the baseline (ΔHbA1c) and the incidence of hypoglycemia.
We assumed that five baseline parameters (HbA1c, fasting blood glucose, body mass index (BMI), duration of type 2 DM, and duration of treatment) could affect ΔHbA1c.
Regarding the incidence of hypoglycemia, we suspected that the heterogeneity was caused by differences in the definition of hypoglycemia among the studies.
Results.
Data obtained from 11 studies (n=4654 patients) were included in the analysis.
The mean ΔHbA1c between the DPP-4 inhibitor and placebo groups was -0.61% (95% confidence interval (CI): -0.74 to -0.48, I2=73.4%).
There was substantial heterogeneity among the 11 studies, but 74.1% of this variability was explained by the difference in BMI.
The odds ratio for the incidence of hypoglycemia was 1.02 (95% CI: 0.74 to 1.42, I2=63.8%), with substantial heterogeneity due to differences in the definition of hypoglycemia among the studies.
There was no apparent effect of publication bias.
Conclusions.
The addition of DPP-4 inhibitors to insulin therapy for adult patients with type 2 DM can significantly reduce HbA1c levels without increasing the occurrence of hypoglycemia.
BMI and hypoglycemia definition could explain the heterogeneity in the clinical trials.
This trial is registered with PROSPERO #CRD42016035994.
American Psychological Association (APA)
Shibuki, Katsuya& Shimada, Shuji& Aoyama, Takao. 2020. Meta-Analysis of 11 Heterogeneous Studies regarding Dipeptidyl Peptidase 4 Inhibitor Add-On Therapy for Type 2 Diabetes Mellitus Patients Treated with Insulin. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1183271
Modern Language Association (MLA)
Shibuki, Katsuya…[et al.]. Meta-Analysis of 11 Heterogeneous Studies regarding Dipeptidyl Peptidase 4 Inhibitor Add-On Therapy for Type 2 Diabetes Mellitus Patients Treated with Insulin. Journal of Diabetes Research No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1183271
American Medical Association (AMA)
Shibuki, Katsuya& Shimada, Shuji& Aoyama, Takao. Meta-Analysis of 11 Heterogeneous Studies regarding Dipeptidyl Peptidase 4 Inhibitor Add-On Therapy for Type 2 Diabetes Mellitus Patients Treated with Insulin. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1183271
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183271