Association of PD-1 and PD-L1 Genetic Polymorphyisms with Type 1 Diabetes Susceptibility
Joint Authors
Li, Sicheng
Fang, Chen
Qian, Chenyue
Guo, Heming
Chen, Xiaohong
Shi, Aiming
Wang, Xin
Pan, Jie
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aims.
The programmed death- (PD-) 1/PD-1 ligand (PD-L) pathway plays an important role in regulating T cell activation and maintaining peripheral tolerance.
Accumulated studies showed that PD-1/PD-L1 pathway was involved in the development of type 1 diabetes (T1DM).
Since the genetic background of type 1 diabetes differs greatly among the different population, we aim to investigate the association of genetic polymorphisms in PD-1 and PD-L1 with T1DM susceptibility in Chinese population.
Methods.
In total, 166 T1DM patients and 100 healthy controls were enrolled into the study.
Genomic DNA was extracted from 4 mL peripheral blood samples collected from each subject.
Genotyping of 8 selected SNPs of PD-1 and PD-L1 was carried out by the pyrosequencing PSQ 24 System using PyroMark Gold reagents (QIAGEN).
Results.
SNP rs4143815 in PD-L1 was significantly associated with T1DM.
People carrying the C allele of rs4143815 suffering less risk of T1DM and T1DM patients with G/G genotype showed higher levels of autoantibody (AAB) positive incidence compared with C allele carriers.
No significant associations were found in other SNPs.
Conclusions.
Our results indicate that rs4143815 of PD-L1 is significantly associated with T1DM and may serve as a new biomarker to predict the T1DM susceptibility.
American Psychological Association (APA)
Qian, Chenyue& Guo, Heming& Chen, Xiaohong& Shi, Aiming& Li, Sicheng& Wang, Xin…[et al.]. 2018. Association of PD-1 and PD-L1 Genetic Polymorphyisms with Type 1 Diabetes Susceptibility. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1183279
Modern Language Association (MLA)
Qian, Chenyue…[et al.]. Association of PD-1 and PD-L1 Genetic Polymorphyisms with Type 1 Diabetes Susceptibility. Journal of Diabetes Research No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1183279
American Medical Association (AMA)
Qian, Chenyue& Guo, Heming& Chen, Xiaohong& Shi, Aiming& Li, Sicheng& Wang, Xin…[et al.]. Association of PD-1 and PD-L1 Genetic Polymorphyisms with Type 1 Diabetes Susceptibility. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1183279
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183279