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Modification of Alginate Hydrogel Films for Delivering Hydrophobic Kaempferol
Joint Authors
Ye, Yuanfeng
Zhang, Xiaojuan
Hao, Lingyun
Deng, Xiang
Wang, Wei
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The high hydrophilicity of alginate materials makes delivering a high load of hydrophobic drug difficult.
To overcome this drawback, sodium alginate (SA) was modified using octylamine (OA), and then kaempferol (KP) was combined with the alginate solution through the hydrophobic interaction between OA and KP.
The modified SA/KP (MSA/KP) hydrogel films were ionically cross-linked by immersing in calcium chloride solution.
Subsequently, the products were analyzed via Fourier transform infrared spectroscopy, scanning electron microscopy, contact angle test, thermogravimetric analysis, swelling analysis, water vapor transmission, and mechanical property test.
Results showed that compared with the SA hydrogel films, the MSA/KP hydrogel films exhibited an interporous structure, good swelling, and mechanical properties.
Moreover, the drug release experiments demonstrated that the MSA/KP hydrogel films achieved a KP encapsulation efficiency of 70.4%, with a sustained KP release of up to 80 h.
The cell viability experiments demonstrated that the MSA/KP hydrogel films posed no evident cytotoxicity to human umbilical vein endothelial cells.
American Psychological Association (APA)
Ye, Yuanfeng& Zhang, Xiaojuan& Deng, Xiang& Hao, Lingyun& Wang, Wei. 2019. Modification of Alginate Hydrogel Films for Delivering Hydrophobic Kaempferol. Journal of Nanomaterials،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1183333
Modern Language Association (MLA)
Ye, Yuanfeng…[et al.]. Modification of Alginate Hydrogel Films for Delivering Hydrophobic Kaempferol. Journal of Nanomaterials No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1183333
American Medical Association (AMA)
Ye, Yuanfeng& Zhang, Xiaojuan& Deng, Xiang& Hao, Lingyun& Wang, Wei. Modification of Alginate Hydrogel Films for Delivering Hydrophobic Kaempferol. Journal of Nanomaterials. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1183333
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183333