Effects of Metformin Added to Insulin in Adolescents with Type 1 Diabetes: An Exploratory Crossover Randomized Trial

Joint Authors

Yang, Daizhi
Yan, Jinhua
Deng, Hongrong
Yang, Xubin
Luo, Sihui
Zheng, Xueying
Lv, Jing
Liang, Wen
Hong, Mengjie
Wu, Zekai
Yao, Bin
Weng, Jianping
Xu, Wen

Source

Journal of Diabetes Research

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-12-29

Country of Publication

Egypt

No. of Pages

10

Main Topic

Diseases
Medicine

Abstract EN

Background.

To comprehensively assess the effects of metformin added to insulin on metabolic control, insulin sensitivity, and cardiovascular autonomic function in adolescents with type 1 diabetes.

Materials and Methods.

This was an exploratory, crossover, randomized trial conducted in adolescents with type 1 diabetes aged 12-18 years old.

Participants were randomly received metformin (≤1000 mg/d) added to insulin for 24 weeks followed by insulin monotherapy for a subsequent 24 weeks or vice versa.

Blood pressure, body mass index, insulin dose, estimated insulin sensitivity, glycated hemoglobin A1c (HbA1c), and lipid profiles were measured, with a 72-hour continuous glucose monitoring and 24-hour Holter monitoring performed at baseline, 24, and 50 weeks for the assessments of glucose variability and heart rate variability.

Results.

Seventeen patients with mean±SD age 14.4±2.3 years, body mass index 18.17±1.81 kg/m2, median (IQR) diabetes duration 4.50 (3.58, 6.92) years, and HbA1c 9.0% (8.5%, 9.4%) were enrolled.

The between-group difference in HbA1c of 0.28% (95% CI -0.39 to 0.95%) was not significant (P=0.40).

Changes in body mass index, insulin dose, blood pressure, lipid profiles, and estimated insulin sensitivity were similar for metformin add-on vs.

insulin monotherapy.

Glucose variability also did not differ.

Compared with insulin monotherapy, metformin add-on significantly increased multiple heart rate variability parameters.

Conclusions.

Metformin added to insulin did not improve metabolic control or glucose variability in lean/normal-weight adolescents with type 1 diabetes.

However, metformin added to insulin significantly increased heart rate variability, suggesting that metformin might improve cardiovascular autonomic function in this population.

American Psychological Association (APA)

Yang, Daizhi& Yan, Jinhua& Deng, Hongrong& Yang, Xubin& Luo, Sihui& Zheng, Xueying…[et al.]. 2020. Effects of Metformin Added to Insulin in Adolescents with Type 1 Diabetes: An Exploratory Crossover Randomized Trial. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1183376

Modern Language Association (MLA)

Yang, Daizhi…[et al.]. Effects of Metformin Added to Insulin in Adolescents with Type 1 Diabetes: An Exploratory Crossover Randomized Trial. Journal of Diabetes Research No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1183376

American Medical Association (AMA)

Yang, Daizhi& Yan, Jinhua& Deng, Hongrong& Yang, Xubin& Luo, Sihui& Zheng, Xueying…[et al.]. Effects of Metformin Added to Insulin in Adolescents with Type 1 Diabetes: An Exploratory Crossover Randomized Trial. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1183376

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1183376