Research Progress on the Pathological Mechanisms of Podocytes in Diabetic Nephropathy
Joint Authors
Zhao, Linhua
Tong, Xiaolin
Han, Lin
Wang, Xinmiao
Zheng, Yujiao
Zhang, Lili
Wen, Zhige
Wei, Yu
Wang, Qing
Fang, Xinyi
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-10
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Diabetic nephropathy (DN) is not only an important microvascular complication of diabetes but also the main cause of end-stage renal disease.
Studies have shown that the occurrence and development of DN are closely related to morphological and functional changes in podocytes.
A series of morphological changes after podocyte injury in DN mainly include podocyte hypertrophy, podocyte epithelial-mesenchymal transdifferentiation, podocyte detachment, and podocyte apoptosis; functional changes mainly involve podocyte autophagy.
More and more studies have shown that multiple signaling pathways play important roles in the progression of podocyte injury in DN.
Here, we review research progress on the pathological mechanism of morphological and functional changes in podocytes associated with DN, to provide a new target for delaying the occurrence and development of this disorder.
American Psychological Association (APA)
Zhang, Lili& Wen, Zhige& Han, Lin& Zheng, Yujiao& Wei, Yu& Wang, Xinmiao…[et al.]. 2020. Research Progress on the Pathological Mechanisms of Podocytes in Diabetic Nephropathy. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1183385
Modern Language Association (MLA)
Zhang, Lili…[et al.]. Research Progress on the Pathological Mechanisms of Podocytes in Diabetic Nephropathy. Journal of Diabetes Research No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1183385
American Medical Association (AMA)
Zhang, Lili& Wen, Zhige& Han, Lin& Zheng, Yujiao& Wei, Yu& Wang, Xinmiao…[et al.]. Research Progress on the Pathological Mechanisms of Podocytes in Diabetic Nephropathy. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1183385
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183385