Preparation of Fe3O4Reduced Graphene Oxide Nanocomposites with Good Dispersibility for Delivery of Paclitaxel
Joint Authors
Lin, Qing
Zhang, Xiaojuan
Hao, Lingyun
Cai, Wenbin
Feng, Suli
Jiang, Wei
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The Fe3O4/reduced graphene oxide (Fe3O4/RGO) nanocomposites with good dispersibility were synthesized for targeted delivery of paclitaxel (PTX).
Firstly, the superparamagnetic Fe3O4/functional GO nanocomposites were prepared via hydrothermal method in which GO sheets were modified by surfactant wrapping.
The Fe3O4/RGO nanocomposites were successively prepared through the reduction of graphene oxide.
The products were investigated by Fourier-transform infrared spectrum, X-ray diffraction, scanning electron microscopy, transmission electron microscopy, thermogravimetric analysis, and vibration sample magnetometry.
It was found that spherical Fe3O4 nanoparticles were uniformly anchored over the RGO matrix and the nanocomposites were superparamagnetic with saturation magnetization (Ms) of 9.39 emu/g.
Then PTX was loaded onto Fe3O4/RGO nanocomposites, and the drug loading capacity was 67.9%.
Cell viability experiments performed on MCF-7 demonstrated that the Fe3O4/RGO-loaded PTX (Fe3O4/RGO/PTX) showed cytotoxicity to MCF-7, whereas the Fe3O4/RGO displayed no obvious cytotoxicity.
The above results indicated that Fe3O4/RGO/PTX nanocomposites had potential application in tumor-targeted chemotherapy.
American Psychological Association (APA)
Zhang, Xiaojuan& Cai, Wenbin& Hao, Lingyun& Feng, Suli& Lin, Qing& Jiang, Wei. 2017. Preparation of Fe3O4Reduced Graphene Oxide Nanocomposites with Good Dispersibility for Delivery of Paclitaxel. Journal of Nanomaterials،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1183398
Modern Language Association (MLA)
Zhang, Xiaojuan…[et al.]. Preparation of Fe3O4Reduced Graphene Oxide Nanocomposites with Good Dispersibility for Delivery of Paclitaxel. Journal of Nanomaterials No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1183398
American Medical Association (AMA)
Zhang, Xiaojuan& Cai, Wenbin& Hao, Lingyun& Feng, Suli& Lin, Qing& Jiang, Wei. Preparation of Fe3O4Reduced Graphene Oxide Nanocomposites with Good Dispersibility for Delivery of Paclitaxel. Journal of Nanomaterials. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1183398
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183398