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Calcium Signaling in the Ventricular Myocardium of the Goto-Kakizaki Type 2 Diabetic Rat
Joint Authors
Singh, Jaipaul
Sydorenko, Vadym
Al Kury, L.
Smail, M.
Qureshi, M. A.
Shmygol, A.
Oz, M.
Howarth, F. C.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-10
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The association between diabetes mellitus (DM) and high mortality linked to cardiovascular disease (CVD) is a major concern worldwide.
Clinical and preclinical studies have demonstrated a variety of diastolic and systolic dysfunctions in patients with type 2 diabetes mellitus (T2DM) with the severity of abnormalities depending on the patients’ age and duration of diabetes.
The cellular basis of hemodynamic dysfunction in a type 2 diabetic heart is still not well understood.
The aim of this review is to evaluate our current understanding of contractile dysfunction and disturbances of Ca2+ transport in the Goto-Kakizaki (GK) diabetic rat heart.
The GK rat is a widely used nonobese, nonhypertensive genetic model of T2DM which is characterized by insulin resistance, elevated blood glucose, alterations in blood lipid profile, and cardiac dysfunction.
American Psychological Association (APA)
Al Kury, L.& Smail, M.& Qureshi, M. A.& Sydorenko, Vadym& Shmygol, A.& Oz, M.…[et al.]. 2018. Calcium Signaling in the Ventricular Myocardium of the Goto-Kakizaki Type 2 Diabetic Rat. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1183400
Modern Language Association (MLA)
Al Kury, L.…[et al.]. Calcium Signaling in the Ventricular Myocardium of the Goto-Kakizaki Type 2 Diabetic Rat. Journal of Diabetes Research No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1183400
American Medical Association (AMA)
Al Kury, L.& Smail, M.& Qureshi, M. A.& Sydorenko, Vadym& Shmygol, A.& Oz, M.…[et al.]. Calcium Signaling in the Ventricular Myocardium of the Goto-Kakizaki Type 2 Diabetic Rat. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1183400
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183400