A Putative Prohibitin-Calcium Nexus in β-Cell Mitochondria and Diabetes
Joint Authors
Dixit, Aparna
Nunemaker, Craig S.
Verma, Gaurav
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The role of mitochondria in apoptosis is well known; however, the mechanisms linking mitochondria to the proapoptotic effects of proinflammatory cytokines, hyperglycemia, and glucolipotoxicity are not completely understood.
Complex Ca2+ signaling has emerged as a critical contributor to these proapoptotic effects and has gained significant attention in regulating the signaling processes of mitochondria.
In pancreatic β-cells, Ca2+ plays an active role in β-cell function and survival.
Prohibitin (PHB), a mitochondrial chaperone, is actively involved in maintaining the architecture of mitochondria.
However, its possible interaction with Ca2+-activated signaling pathways has not been explored.
The present review aims to examine potential crosstalk between Ca2+ signaling and PHB function in pancreatic β-cells.
Moreover, this review will focus on the effects of cytokines and glucolipotoxicity on Ca2+ signaling and its possible interaction with PHB.
Improved understanding of this important mitochondrial protein may aid in the design of more targeted drugs to identify specific pathways involved with stress-induced dysfunction in the β-cell.
American Psychological Association (APA)
Verma, Gaurav& Dixit, Aparna& Nunemaker, Craig S.. 2020. A Putative Prohibitin-Calcium Nexus in β-Cell Mitochondria and Diabetes. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1183412
Modern Language Association (MLA)
Verma, Gaurav…[et al.]. A Putative Prohibitin-Calcium Nexus in β-Cell Mitochondria and Diabetes. Journal of Diabetes Research No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1183412
American Medical Association (AMA)
Verma, Gaurav& Dixit, Aparna& Nunemaker, Craig S.. A Putative Prohibitin-Calcium Nexus in β-Cell Mitochondria and Diabetes. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1183412
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183412