Diagnosis of Gestational Diabetes Mellitus with Point-of-Care Methods for Glucose versus Hospital Laboratory Method Using Isotope Dilution Gas Chromatography-Mass Spectrometry as Reference
Joint Authors
Simmons, David
Katsarou, Anastasia
Shaat, Nael
Berntorp, Kerstin
Kristensen, Karl
Wangel, Anne-Marie
Fadl, Helena
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
In Sweden, both glucose analyzers in accredited laboratories and point-of-care glucose devices are used for gestational diabetes mellitus (GDM) diagnosis.
The aim of this study was to compare the diagnostic performance of the HemoCue Glucose 201+ (HC201+) and RT (HC201RT) systems with that of the hospital central laboratory hexokinase method (CL) based on lyophilized citrate tubes, using the isotope dilution gas chromatography-mass spectrometry (ID GC-MS) as reference.
Methods.
A 75 g oral glucose tolerance test was performed on 135 women screened positive for GDM.
Diagnosis was based on the World Health Organization 2013 diagnostic thresholds for fasting (n=135), 1 h (n=52), and 2 h (n=135) glucose measurements.
Bland-Altman analysis and surveillance error grids were used to evaluate analytical and clinical accuracy.
Results.
Significantly more women were diagnosed with GDM by HC201+ (80%) and CL (80%) than with the reference (65%, P<0.001) based on fasting and/or 2 h thresholds, whereas the percentage diagnosed by HC201RT (60%) did not differ significantly from the reference.
In Bland-Altman analysis, a positive bias was observed for HC201+ (4.2%) and CL (6.1%) and a negative bias for HC201RT (−1.8%).
In the surveillance error grid, 95.9% of the HC201+ values were in the no-risk zone as compared to 98.1% for HC201RT and 97.5% for CL.
Conclusions.
A substantial positive bias was found for CL measurements resulting in overdiagnosis of GDM.
Our findings suggest better performance of HC201RT than HC201+ in GDM diagnosis.
The results may have possible implications for GDM diagnosis in Sweden and require further elucidation.
American Psychological Association (APA)
Kristensen, Karl& Wangel, Anne-Marie& Katsarou, Anastasia& Shaat, Nael& Simmons, David& Fadl, Helena…[et al.]. 2020. Diagnosis of Gestational Diabetes Mellitus with Point-of-Care Methods for Glucose versus Hospital Laboratory Method Using Isotope Dilution Gas Chromatography-Mass Spectrometry as Reference. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1183427
Modern Language Association (MLA)
Kristensen, Karl…[et al.]. Diagnosis of Gestational Diabetes Mellitus with Point-of-Care Methods for Glucose versus Hospital Laboratory Method Using Isotope Dilution Gas Chromatography-Mass Spectrometry as Reference. Journal of Diabetes Research No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1183427
American Medical Association (AMA)
Kristensen, Karl& Wangel, Anne-Marie& Katsarou, Anastasia& Shaat, Nael& Simmons, David& Fadl, Helena…[et al.]. Diagnosis of Gestational Diabetes Mellitus with Point-of-Care Methods for Glucose versus Hospital Laboratory Method Using Isotope Dilution Gas Chromatography-Mass Spectrometry as Reference. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1183427
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183427