Thrombospondin-1: A Key Protein That Induces Fibrosis in Diabetic Complications
Joint Authors
Xu, Linhao
Zhang, Yong
Chen, Jian
Xu, Yizhou
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-12
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Fibrosis accompanies most common pathophysiological features of diabetes complications in different organs.
It is characterized by an excessive accumulation of extracellular matrix (ECM) components, the response to which contributes to inevitable organ injury.
The extracellular protein thrombospondin-1 (TSP-1), a kind of extracellular glycoprotein, is upregulated by the increased activity of some transcription factors and results in fibrosis by activating multiple pathways in diabetes.
The results of studies from our team and other colleagues indicate that TSP-1 is associated with the pathological process leading to diabetic complications and is considered to be the most important factor in fibrosis.
This review summarizes the molecular mechanism of increased TSP-1 induced by hyperglycemia and the role of TSP-1 in fibrosis during the development of diabetes complications.
American Psychological Association (APA)
Xu, Linhao& Zhang, Yong& Chen, Jian& Xu, Yizhou. 2020. Thrombospondin-1: A Key Protein That Induces Fibrosis in Diabetic Complications. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1183439
Modern Language Association (MLA)
Xu, Linhao…[et al.]. Thrombospondin-1: A Key Protein That Induces Fibrosis in Diabetic Complications. Journal of Diabetes Research No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1183439
American Medical Association (AMA)
Xu, Linhao& Zhang, Yong& Chen, Jian& Xu, Yizhou. Thrombospondin-1: A Key Protein That Induces Fibrosis in Diabetic Complications. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1183439
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183439