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Genetic and Biological Effects of ICAM-1 E469K Polymorphism in Diabetic Kidney Disease
Joint Authors
Brismar, Kerstin
Falhammar, Henrik
Zhang, Xiuli
Seman, Norhashimah Abu
Gu, Harvest F.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Diabetic kidney disease (DKD) is a complex disease, in which local inflammatory stress results from both metabolic and hemodynamic derangements.
Intercellular adhesion molecule 1 (ICAM-1) is an acute-phase protein marker of inflammation.
In the recent years, clinical observations have reported that increased serum/plasma ICAM-1 levels are positively correlated with albuminuria in the patients with type 1 (T1D) and type 2 diabetes (T2D).
Genetic association studies have demonstrated that genetic polymorphisms, including SNP rs5498 (E469K, G/A), in the ICAM1 gene is associated with DKD.
rs5498 is a nonsynonymous SNP and caused by substitution between E (Glu) and K (Lys) for ICAM-1 protein.
In this review, we first summarized the genetic effects of ICAM1 E469K polymorphism in DKD and then demonstrated the possible changes of ICAM-1 protein crystal structures according to the genotypes of this polymorphism.
Finally, we discussed the genetic effects of the ICAM1 E469K polymorphism and the biological role of increased circulating ICAM-1 protein and its formation changes in DKD.
American Psychological Association (APA)
Zhang, Xiuli& Seman, Norhashimah Abu& Falhammar, Henrik& Brismar, Kerstin& Gu, Harvest F.. 2020. Genetic and Biological Effects of ICAM-1 E469K Polymorphism in Diabetic Kidney Disease. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1183451
Modern Language Association (MLA)
Zhang, Xiuli…[et al.]. Genetic and Biological Effects of ICAM-1 E469K Polymorphism in Diabetic Kidney Disease. Journal of Diabetes Research No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1183451
American Medical Association (AMA)
Zhang, Xiuli& Seman, Norhashimah Abu& Falhammar, Henrik& Brismar, Kerstin& Gu, Harvest F.. Genetic and Biological Effects of ICAM-1 E469K Polymorphism in Diabetic Kidney Disease. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1183451
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183451