Association between LXR-α and ABCA1 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus in a Chinese Han Population
Joint Authors
Zhang, Haojun
Yan, Meihua
Qiu, Xinping
Ma, Liang
Zhao, Hailing
Zhou, Xuefeng
Li, Ping
Zhao, Tingting
Liu, Peng
Shen, Zhengri
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We designed a case-control study and selected LXR-α rs7120118 C>T and ABCA1 rs2230806 A>G polymorphisms to determine the correlation between these polymorphisms and diabetic kidney disease (DKD) susceptibility in a Chinese Han population.
Three hundred DKD patients and 346 type 2 diabetes mellitus (DM) patients without kidney disease were recruited.
Our results showed that rs7120118 was associated with DKD (genotype, P=.027; allele, P<.011).
rs7120118 was associated with a higher risk of DKD under a dominant model adjustment by age and sex (P=.015) and an additive model (P=.040); rs2230806 was associated with a higher risk of DKD under an recessive model (P<.03); the combined effect of rs7120118 CC+rs2230806 GG genotype showed an association of DKD adjustment for age and sex (P=.009).
In subgroup analysis of patients without hypercholesterolemia, the rs2230806 genotype frequencies were different between the two groups (P=.042).
rs2230806 was associated with increased risk of DKD under a recessive model adjustment for age and sex (P=.013) and an additive model (P=.031).
Our results suggest that LXR-α rs7120118 is significantly associated with a higher risk of DKD, and ABCA1 rs2230806 is significantly associated with a higher risk of DKD without hypercholesterolemia in Chinese Han individuals.
American Psychological Association (APA)
Liu, Peng& Ma, Liang& Zhao, Hailing& Shen, Zhengri& Zhou, Xuefeng& Yan, Meihua…[et al.]. 2020. Association between LXR-α and ABCA1 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus in a Chinese Han Population. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1183466
Modern Language Association (MLA)
Liu, Peng…[et al.]. Association between LXR-α and ABCA1 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus in a Chinese Han Population. Journal of Diabetes Research No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1183466
American Medical Association (AMA)
Liu, Peng& Ma, Liang& Zhao, Hailing& Shen, Zhengri& Zhou, Xuefeng& Yan, Meihua…[et al.]. Association between LXR-α and ABCA1 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus in a Chinese Han Population. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1183466
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183466