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Studies of the Influence of Gold Nanoparticles on Characteristics of Mesenchymal Stem Cells
Joint Authors
Gulevsky, Alexander Kirillovich
Volkova, Nataliia
Pavlovich, Olena
Fesenko, Olena
Budnyk, Oksana
Kovalchuk, Serhii
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The aim of the present study is to determine what effect the different concentrations of 15 nm gold nanoparticles (AuNPs) will have on the immunophenotype, synthesis collagen type I, ability to direct differentiation and spectroscopic characteristics of bone marrow mesenchymal stem cells (MSCs).
The AuNPs in concentrations of 1.5–9 μg/ml did not lead to changes in the level of expression of CD 45, CD 90, and CD 73.
It should be noted that AuNPs in concentrations of 6 and 9 μg/ml led to a decrease in CD 44 cells by 6% and 9%, respectively.
The content of CD 105 cells was reduced by 5% when AuNPs were applied at a concentration of 9 μg/ml.
It was found that AuNPs in concentrations of 1.5–6 μg/ml are safe for MSCs, while the increase up to 9 μg/ml has a toxic effect, manifested by the reduction of synthesis collagen type I and ability of adipogenic differentiation.
IR spectroscopy data have shown that the AuNPs at concentrations of 9 μg/ml under conditions of adipogenic differentiation to MSCs lead to the destruction processes in the cells.
The obtained results are related to the field of applied nanotechnology, which extends to regenerative medicine, especially in development of bioimplantology.
American Psychological Association (APA)
Volkova, Nataliia& Pavlovich, Olena& Fesenko, Olena& Budnyk, Oksana& Kovalchuk, Serhii& Gulevsky, Alexander Kirillovich. 2017. Studies of the Influence of Gold Nanoparticles on Characteristics of Mesenchymal Stem Cells. Journal of Nanomaterials،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1183473
Modern Language Association (MLA)
Volkova, Nataliia…[et al.]. Studies of the Influence of Gold Nanoparticles on Characteristics of Mesenchymal Stem Cells. Journal of Nanomaterials No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1183473
American Medical Association (AMA)
Volkova, Nataliia& Pavlovich, Olena& Fesenko, Olena& Budnyk, Oksana& Kovalchuk, Serhii& Gulevsky, Alexander Kirillovich. Studies of the Influence of Gold Nanoparticles on Characteristics of Mesenchymal Stem Cells. Journal of Nanomaterials. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1183473
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1183473